Epigenetics, hypersensibility and asthma: what do we know so far?

被引：0

作者：

Lima, Douglas da Silva ^{[1
,2
]}

Morais, Rahuany Velleda de ^{[1
,2
]}

Rechenmacher, Ciliana ^{[1
,2
]}

Michalowski, Mariana Bohns ^{[1
,2
,4
]}

Goldani, Marcelo Zubaran ^{[1
,2
,3
,5
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Pediat, Programa Posgrad Saude Crianca & Adolescente, Porto Alegre, RS, Brazil

[2] Hosp Clin Porto Alegre, Ctr Pesquisa Expt, Lab Pediat Translac, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Porto Alegre, Brazil

[4] Hosp Clin Porto Alegre, Serv Oncol Pediat, Porto Alegre, RS, Brazil

[5] Univ Fed Rio Grande do Sul, Fac Med, Porto Alegre, RS, Brazil

来源：

CLINICS | 2023年 / 78卷

关键词：

Asthma; Children; DNA methylation; Epigenetics; CHILDHOOD ASTHMA; METHYLATION; GENETICS; RISK;

D O I：

10.1016/j.clinsp.2023.100296

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, we describe recent advances in understanding the relationship between epigenetic changes, especially DNA methylation (DNAm), with hypersensitivity and respiratory disorders such as asthma in childhood. It is clearly described that epigenetic mechanisms can induce short to long-term changes in cells, tissues, and organs. Through the growing number of studies on the Origins of Health Development and Diseases, more and more data exist on how environmental and genomic aspects in early life can induce allergies and asthma. The lack of biomarkers, standardized assays, and access to more accessible tools for data collection and analysis are still a challenge for future studies. Through this review, the authors draw a panorama with the available information that can assist in the establishment of an epigenetic approach for the risk analysis of these pathologies.

引用

页数：5

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