Electrochemical chlorination of least hindered tertiary and benzylic C(sp3)-H bonds

被引：13

作者：

Zhao, Jianyou ^{[1
]}

Zhang, Jiatai ^{[1
]}

Fang, Pengkai ^{[1
]}

Wu, Jintao ^{[1
]}

Wang, Fan ^{[1
]}

Liu, Zhong-Quan ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Coll Pharm, Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Nanjing 210023, Peoples R China

来源：

GREEN CHEMISTRY | 2024年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

IRON-CATALYZED BORYLATION; C-H BONDS; HALOGENATION; HYDROXYPHTHALIMIDE; FUNCTIONALIZATION; METHYLARENES; BROMINATION; SILYLATION; ALKYLATION; OXIDATION;

D O I：

10.1039/d3gc03849a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functionalization of C(sp(3))-H bonds should greatly benefit the synthesis of natural products and pharmaceuticals. One of the greatest challenges is to develop new synthetic strategies for industrial applicability. Herein we report an electrochemical method for the chlorination/bromination of tertiary and secondary benzylic C(sp(3))-H bonds. This method tolerates many functional groups. Moreover, this reaction can be easily scaled up to 100 grams without losing its efficiency.

引用

收藏

页码：507 / 512

页数：6

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