Association of IL-4 with pachychoroid neovasculopathy

被引：4

作者：

Baba, Takashi ^{[1
]}

Koyama, Ayumi ^{[1
]}

Uotani, Ryu ^{[1
]}

Miyake, Hitomi ^{[1
]}

Inata, Kodai ^{[1
]}

Sasaki, Shin-ichi ^{[1
]}

Shimizu, Yumiko ^{[1
]}

Inoue, Yoshitsugu ^{[1
]}

Adachi, Kaori ^{[2
]}

Nanba, Eiji ^{[2
,3
]}

Miyazaki, Dai ^{[1
]}

机构：

[1] Tottori Univ, Fac Med, Div Ophthalmol & Visual Sci, 36-1 Nishicho, Yonago, Tottori 6838504, Japan

[2] Tottori Univ, Res Initiat Ctr, Org Res Initiat & Promot, Yonago, Tottori, Japan

[3] Otani Hosp, Tsuyama, Okayama, Japan

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

POLYPOIDAL CHOROIDAL VASCULOPATHY; HUMAN ENDOTHELIAL-CELLS; AQUEOUS-HUMOR; GENE-EXPRESSION; INTERLEUKIN-4; PATHWAY; DISEASE; VCAM-1;

D O I：

10.1038/s41598-023-28108-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The purpose of this study was to identify the inflammatory cytokines that were associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of intraocular cytokines. In eyes with PNV, the levels of IL-1 alpha, IL-1 beta, IL-2, IL-4, IL-10, and VEGF were significantly higher than that of the controls. Logistic regression analysis showed that the highest association with the pachyvessels was found for IL-4, IL-2, and IL-1 alpha. In eyes with PNV, the levels of IL-4, IL-2, IL-5, IL-13, IL-1 alpha, and IL-1 beta were significantly higher in eyes with both increased choroidal thickness and choroidal vessel diameter. The strongest correlation with the choroidal thickness and vessel diameter was observed for IL-4. In PNV eyes with polypoidal lesions, the levels of IL-4, IL-17, and TNF beta were significantly correlated with the number of polypoidal lesions. Of these cytokines, IL-4 was especially associated with the thickness of the choroidal vessels and the formation of polypoidal lesions. We conclude that IL-4 is most likely involved in establishing the clinical characteristics of PNV and polypoidal vascular remodeling.

引用

页数：10

共 53 条

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