SARS-CoV-2 and Other Respiratory Viruses in Human Olfactory Pathophysiology

被引:5
作者
Wade, Serigne Fallou [1 ]
Diouara, Abou Abdallah Malick [2 ]
Ngom, Babacar [1 ]
Thiam, Fatou [2 ]
Dia, Ndongo [3 ]
机构
[1] Univ Amadou Makhtar MBOW, Ecole Super Sci Agr & Alimentat, Rue 21x20,2eme Arrondissement,POB 45927, Dakar, Senegal
[2] Univ Cheikh Anta Diop, Ecole Super Polytech, Grp Rech Biotechnol Appl & Bioprocedes environneme, POB 5085, Dakar, Senegal
[3] Inst Pasteur, Virol Dept, 36 Ave Pasteur,POB 220, Dakar, Senegal
关键词
respiratory viruses; anosmia; olfaction disorders; loss of smell; COVID-19; CELL ENTRY; MERS-COV; RECEPTOR; INFECTION; TRACT; CORONAVIRUS; EPITHELIUM; FAMILY; ICAM-1; IDENTIFICATION;
D O I
10.3390/microorganisms12030540
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Acute respiratory viruses (ARVs) are the leading cause of diseases in humans worldwide. High-risk individuals, including children and the elderly, could potentially develop severe illnesses that could result in hospitalization or death in the worst case. The most common ARVs are the Human respiratory syncytial virus, Human Metapneumovirus, Human Parainfluenza Virus, rhinovirus, coronaviruses (including SARS and MERS CoV), adenoviruses, Human Bocavirus, enterovirus (-D68 and 71), and influenza viruses. The olfactory deficits due to ARV infection are a common symptom among patients. This review provides an overview of the role of SARS-CoV-2 and other common ARVs in the development of human olfactory pathophysiology. We highlight the critical need to understand the signaling underlying the olfactory dysfunction and the development of therapeutics for this wide-ranging category of AVRs to restore the altered or loss of smell in affected patients.
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页数:21
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