Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis

被引：33

作者：

Yiu, Ching-Yi ^{[1
,2
]}

Liu, Chien-Cheng ^{[3
,4
,5
]}

Wu, Jheng-Yan ^{[6
]}

Tsai, Wen-Wen ^{[7
]}

Liu, Ping-Hsin ^{[8
]}

Cheng, Wan-Jung ^{[9
]}

Chen, Jen-Yin ^{[10
,11
]}

Hung, Kuo-Chuan ^{[10
,11
]}

机构：

[1] Chi Mei Med Ctr, Dept Otolaryngol, Tainan 73657, Taiwan

[2] Min Hwei Jr Coll Hlth Care Management, Dept Dent Lab Technol, Tainan 73658, Taiwan

[3] I Shou Univ, E Da Hosp, Dept Anesthesiol, Kaohsiung 82445, Taiwan

[4] I Shou Univ, Coll Med, Dept Nursing, Kaohsiung 82445, Taiwan

[5] I Shou Univ, Sch Med, Kaohsiung 82445, Taiwan

[6] Chi Mei Med Ctr, Dept Nutr, Tainan 71004, Taiwan

[7] Chi Mei Med Ctr, Dept Neurol, Tainan 71004, Taiwan

[8] I Shou Univ, E Da Dachang Hosp, Dept Anesthesiol, Kaohsiung 82445, Taiwan

[9] Chi Mei Med Ctr, Dept Anesthesiol, Tainan 73657, Taiwan

[10] Chi Mei Med Ctr, Dept Anesthesiol, Tainan 71004, Taiwan

[11] Natl Sun Yat Sen Univ, Coll Med, Sch Med, Kaohsiung 804201, Taiwan

来源：

NUTRIENTS | 2023年 / 15卷 / 20期

关键词：

geriatric nutritional risk index; head and neck cancer; overall survival; meta-analysis; EPIDEMIOLOGY;

D O I：

10.3390/nu15204348

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Head and neck cancer (HNC) is a prevalent malignancy with a poor prognosis, necessitating the identification of prognostic biomarkers to guide management. The geriatric nutritional risk index (GNRI), calculated from serum albumin and body weight, may predict survival in patients with HNC. We performed a systematic review and meta-analysis to clarify this relationship. Databases were searched for studies examining the association between pretreatment GNRI and overall survival in patients with HNC. Ten studies with 2793 patients were included. Meta-analysis demonstrated that low GNRI was associated with significantly worse overall survival compared to high GNRI (hazard ratio [HR]:2.84, 95% CI 2.07-3.91, p < 0.00001). Older age (HR:1.73; 95% CI, 1.35-2.22; p < 0.0001), male sex (HR:1.7; 95% CI, 1.12-2.6; p = 0.01), advanced tumor stage (HR: 2.5; 95% CI, 1.72-3.63; p < 0.00001), and higher T-/N-stage (HR = 1.69 and 1.98, respectively) were also predictive of unfavorable outcomes. The GNRI had the highest HR, suggesting potent predictive ability. Despite limitations, including retrospective design and potential publication bias, our study indicates that low pretreatment GNRI predicts poor overall survival in patients with HNC. The GNRI is an inexpensive, routinely available biomarker that could improve prognostication and guide management decisions. Additional research is warranted to validate these findings.

引用

页数：15

共 46 条

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