Microfluidic contact lenses for ocular diagnostics and drug delivery

被引：10
作者：
Torun, Hulya [1 ,2 ]
Fazla, Bartu [1 ]
Arman, Samaneh [1 ]
Ozdalgic, Berin [2 ,3 ,4 ]
Yetisen, Ali K. [5 ]
Tasoglu, Savas [2 ,3 ,6 ,7 ]
机构：
[1] Koc Univ, Grad Sch Sci & Engn, Istanbul, Turkiye
[2] Koc Univ, Res Ctr Translat Med, TR-34450 Istanbul, Turkiye
[3] Koc Univ, Fac Engn, Dept Mech Engn, Istanbul, Turkiye
[4] Dogus Univ, Sch Med Serv & Tech, Div Opticianry, Istanbul, Turkiye
[5] Imperial Coll London, Dept Chem Engn, London SW7 2AZ, England
[6] Koc Univ, Arcelik Res Ctr Creat Ind KUAR, Istanbul, Turkiye
[7] Bogazici Univ, Inst Biomed Engn, Istanbul, Turkiye
来源：
NANO SELECT | 2023年 / 4卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
biosensors; corneal health; diagnostics; drug delivery; ocular dysfunction; ophthalmology; tear detection; RELEASE; EYE; TECHNOLOGIES;
D O I：
10.1002/nano.202200202
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The human eye and tear provide essential physiological information for the detection of ocular dysfunctions and therapy monitoring. The measurements of biomarkers in tear composition are critical for disease diagnosis and early interventions. Hence, significant efforts are dedicated to the development of functional contact lenses that can quantify tear analytes and ocular physiological condition. The combination of microfluidics and contact lens technologies offer real-time monitoring of ocular physiology and timely detection of eye disorders through wireless components. This review discusses the fundamentals of microfluidic contact lenses and their diverse applications in ophthalmic diagnostics and drug delivery. It also elucidates the strategies for the commercialization of microfluidic contact lenses to create clinical and point-of-care products.
引用
收藏
页码：79 / 89
页数：11
相关论文
共 62 条
[1]  
Administration F.a.D., 2022, Types of contact lenses
[2]   Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoring [J].
Agaoglu, Sevda ;
Diep, Priscilla ;
Martini, Matthew ;
Samudhyatha, K. T. ;
Baday, Murat ;
Araci, I. Emre .
LAB ON A CHIP, 2018, 18 (22) :3471-3483
[3]   3D Printed Contact Lenses [J].
Alam, Fahad ;
Elsherif, Mohamed ;
AiQattan, Bader ;
Salih, Ahmed ;
Lee, Sung Mun ;
Yetisen, Ali K. ;
Park, Seongjun ;
Butt, Haider .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2021, 7 (02) :794-803
[4]   Prospects for Additive Manufacturing in Contact Lens Devices [J].
Alam, Fahad ;
Elsherif, Mohamed ;
AlQattan, Bader ;
Ali, Murad ;
Ahmed, Israr Muhammad Gulzar ;
Salih, Ahmed ;
Antonysamy, Dennyson Savariraj ;
Yetisen, Ali K. ;
Park, Seongjun ;
Butt, Haider .
ADVANCED ENGINEERING MATERIALS, 2021, 23 (01)
[5]   Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow [J].
Ali, Maryarn ;
Horikawa, Shin ;
Venkatesh, Siddarth ;
Saha, Jishnu ;
Hong, Jong Wook ;
Byrne, Mark E. .
JOURNAL OF CONTROLLED RELEASE, 2007, 124 (03) :154-162
[6]   High-sensitivity liquid-metal-based contact lens sensor for continuous intraocular pressure monitoring [J].
An, Hongbin ;
Chen, Liangzhou ;
Liu, Xiaojun ;
Wang, Xiangyang ;
Liu, Yunfeng ;
Wu, Zhigang ;
Zhao, Bin ;
Zhang, Hong .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2021, 31 (03)
[7]   Microfluidic contact lenses for unpowered, continuous and non-invasive intraocular pressure monitoring [J].
An, Hongbin ;
Chen, Liangzhou ;
Liu, Xiaojun ;
Zhao, Bin ;
Zhang, Hong ;
Wu, Zhigang .
SENSORS AND ACTUATORS A-PHYSICAL, 2019, 295 :177-187
[8]   A method of manufacturing microfluidic contact lenses by using irreversible bonding and thermoforming [J].
An, Hongbin ;
Chen, Liangzhou ;
Liu, Xiaojun ;
Zhao, Bin ;
Ma, Donglin ;
Wu, Zhigang .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2018, 28 (10)
[9]  
Araci I. E., 2018, Contact Lens with a Microfluidic Channel to Monitor Radius of Curvature of Cornea
[10]   Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens [J].
Badugu, R ;
Lakowicz, JR ;
Geddes, CD .
ANALYTICAL CHEMISTRY, 2004, 76 (03) :610-618
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