Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission

被引：0

作者：

Mutemi, Doreen D. ^{[1
,2
,3
]}

Tuju, James ^{[3
]}

Ogwang, Rodney ^{[3
]}

Nyamako, Lydia ^{[3
]}

Wambui, Kennedy M. ^{[3
,4
]}

Cruz, Ivette R. ^{[5
]}

Villner, Paer ^{[5
]}

Yman, Victor ^{[1
,6
]}

Kinyanjui, Samson M. ^{[3
,7
,8
,9
]}

Rooth, Ingegerd ^{[1
,10
]}

Ngasala, Billy ^{[2
,11
]}

Faernert, Anna ^{[1
,12
]}

Osier, Faith H. A. ^{[3
,13
,14
]}

机构：

[1] Karolinska Inst, Dept Med Solna, Div Infect Dis, S-17177 Stockholm, Sweden

[2] Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam 11102, Tanzania

[3] Kenya Govt Med Res Ctr, Wellcome Trust Res Programme, Ctr Geog Med Res Coast, Kilifi 80108, Kenya

[4] Univ Witwatersrand, Sch Publ Hlth, Epidemiol & Biostat Div, ZA-2000 Johannesburg, South Africa

[5] Karolinska Inst, Div Biostat, S-17177 Stockholm, Sweden

[6] Soder Sjukhuset, Dept Infect Dis, S-11861 Stockholm, Sweden

[7] Pwani Univ, Biosci Res Ctr, Kilifi 80108, Kenya

[8] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford OX3 7LG, England

[9] Strathmore Univ, Sch Business Studies, Nairobi 0200, Kenya

[10] Nyamisati Malaria Res Grp, Pwani 61621, Tanzania

[11] Uppsala Univ, Dept Womens & Childrens Hlth, Int Maternal & Child Hlth, S-75105 Uppsala, Sweden

[12] Karolinska Univ Hosp, Dept Infect Dis, S-17176 Stockholm, Sweden

[13] Heidelberg Univ Hosp, Ctr Infect Dis, D-69120 Heidelberg, Germany

[14] Imperial Coll London, Dept Life Sci, London SW7 2AZ, England

来源：

VACCINES | 2024年 / 12卷 / 02期

关键词：

Plasmodium falciparum; malaria; transmission; ADRB; immunity; vaccines; ACQUIRED-IMMUNITY; GAMMA-GLOBULIN; BLOOD; NEUTROPHILS; CHILDREN;

D O I：

10.3390/vaccines12020203

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria transmission intensity affects the development of naturally acquired immunity to malaria. An absolute correlate measure of protection against malaria is lacking. However, antibody-mediated functions against Plasmodium falciparum correlate with protection against malaria. In children, antibody-mediated functions against P. falciparum decline with reduced exposure. It is unclear whether adults maintain antibody-mediated functions as malaria transmission declines. This study assessed antibody-dependent respiratory burst (ADRB) in individuals from an area with declining malaria transmission. In an age-matched analysis, we compare ADRB activity during high versus low malaria transmission periods. Age significantly predicted higher ADRB activity in the high (p < 0.001) and low (p < 0.001) malaria transmission periods. ADRB activity was higher during the high compared to the low malaria transmission period in older children and adults. Only older adults during the high malaria transmission period had their median ADRB activity above the ADRB cut-off. Ongoing P. falciparum infection influenced ADRB activity during the low (p = 0.01) but not the high (p = 0.29) malaria transmission period. These findings propose that naturally acquired immunity to P. falciparum is affected in children and adults as malaria transmission declines, implying that vaccines will be necessary to induce and maintain protection against malaria.

引用

页数：14

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