First use of imlifidase desensitization in a highly sensitized lung transplant candidate: a case report

被引：8

作者：

Roux, Antoine ^{[1
,2
,3
,4
,13
,14
]}

Bunel, Vincent ^{[5
]}

Belousova, Natalia ^{[1
,2
]}

Messika, Jonathan ^{[5
]}

Tanaka, Sebastien ^{[6
]}

Salpin, Mathilde ^{[5
]}

Roussel, Arnaud ^{[7
]}

Beaumont-Azuar, Laurence ^{[1
,2
]}

Picard, Clement ^{[1
,2
]}

Brugiere, Olivier ^{[1
,2
]}

Devaquet, Jerome ^{[8
]}

Sage, Edouard ^{[9
]}

Le Guen, Morgan ^{[10
]}

Taupin, Jean-Luc ^{[11
]}

Devriese, Magali ^{[11
]}

Glorion, Mathieu ^{[9
]}

Parquin, Francois ^{[12
]}

机构：

[1] Foch Hosp, Adult Cyst Fibrosis Ctr, Pneumol, Suresnes, France

[2] Foch Hosp, Lung Transplantat Dept, Suresnes, France

[3] Univ Versailles St Quentin en Yvelines, UMR 0892, Versailles, France

[4] Paris Transplant Grp, INSERM U 970s, Paris, France

[5] Hop Xavier Bichat, Pneumol Dept, Paris, France

[6] Hop Xavier Bichat, Intens Care Dept, Paris, France

[7] Hop Xavier Bichat, Thorac Surg Dept, Paris, France

[8] Foch Hosp, Intens Care Unit, Suresnes, France

[9] Foch Hosp, Thorac Surg Dept, Suresnes, France

[10] Foch Hosp, Anesthesiol Dept, Suresnes, France

[11] St Louis Hosp, Assistance Publ Hop Paris, Lab Reg Histocompatibil, Paris, France

[12] Foch Hosp, Thorac Intens Care Unit, Suresnes, France

[13] Foch Hosp, Adult Cyst Fibrosis Ctr, Pneumol, 40 Rue Worth, F-92150 Suresnes, France

[14] Foch Hosp, Lung Transplantat Dept, 40 Rue Worth, F-92150 Suresnes, France

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2023年 / 23卷 / 02期

关键词：

clinical research; practice; histocompatibility; immunosuppression; immune modulation; lung transplantation; pulmonology; crossmatch; desensitization; immunosuppressant; -other; rejection; antibody -mediated (ABMR); panel reactive antibody (PRA); HYPERACUTE REJECTION; ANTIBODIES; SURVIVAL;

D O I：

10.1016/j.ajt.2022.11.025

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Lung transplant candidates who are highly sensitized against human leucocyte antigen present an ongoing challenge with regards to finding immunologically acceptable donors. Desensitization strategies aimed at reducing preformed donor-specific antibodies have a number of limitations. Imlifidase, an IgG-degrading enzyme derived from Streptococcus pyogenes, is a novel agent that has been used to convert positive crossmatches to negative in kidney transplant candidates, allowing transplantation to occur. We present the first case of imlifidase use for antibody depletion in a highly sensitized lung transplant candidate who went on to undergo a successful bilateral lung transplant.

引用

页码：294 / 297

页数：4

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