A new approach to overcoming antibiotic-resistant bacteria: Traditional Chinese medicine therapy based on the gut microbiota

被引：9

作者：

Xue, Peng ^{[1
]}

Sang, Rui ^{[2
]}

Li, Nan ^{[3
]}

Du, Siyuan ^{[1
]}

Kong, Xiuwen ^{[1
]}

Tai, Mingliang ^{[1
]}

Jiang, Zhihao ^{[2
]}

Chen, Ying ^{[3
]}

机构：

[1] Nantong Univ, Med Sch, Nantong, Jiangsu, Peoples R China

[2] Nantong Univ, Ctr Basic Med Res, Med Sch, Nantong, Jiangsu, Peoples R China

[3] Nantong Univ, Med Coll, Dept Histol & Embryol, Nantong, Jiangsu, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2023年 / 13卷

基金：

中国国家自然科学基金;

关键词：

traditional Chinese medicine; drug-resistant bacteria; gut microbiota; multi-drug resistance; reversion mechanism; STAPHYLOCOCCUS-AUREUS; SILVER NANOPARTICLES; HELICOBACTER-PYLORI; BIOFILM FORMATION; STREPTOCOCCUS-PNEUMONIAE; ANTIBACTERIAL ACTIVITY; DRUG-RESISTANCE; BERBERINE; MECHANISM; BAICALEIN;

D O I：

10.3389/fcimb.2023.1119037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With the irrational use of antibiotics and the increasing abuse of oral antibiotics, the drug resistance of gastrointestinal pathogens has become a prominent problem in clinical practice. Gut microbiota plays an important role in maintaining human health, and the change of microbiota also affects the activity of pathogenic bacteria. Interfering with antibiotic resistant bacteria by affecting gut microbiota has also become an important regulatory signal. In clinical application, due to the unique advantages of traditional Chinese medicine in sterilization and drug resistance, it is possible for traditional Chinese medicine to improve the gut microbial microenvironment. This review discusses the strategies of traditional Chinese medicine for the treatment of drug-resistant bacterial infections by changing the gut microenvironment, unlocking the interaction between microbiota and drug resistance of pathogenic bacteria.

引用

页数：13

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