Understanding the challenges to COVID-19 vaccines and treatment options, herd immunity and probability of reinfection

被引：4

作者：

Al-Hatamleh, Mohammad A. I. ^{[1
]}

Abusalah, Mai A. ^{[2
]}

Hatmal, Ma'mon M. ^{[3
]}

Alshaer, Walhan ^{[4
]}

Ahmad, Suhana ^{[1
]}

Mohd-Zahid, Manali H. ^{[5
]}

Rahman, Engku Nur Syafirah E. A. ^{[6
]}

Yean, Chan Y. ^{[6
]}

Alias, Iskandar Z. ^{[5
]}

Uskokovic, Vuk ^{[7
]}

Mohamud, Rohimah ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Immunol, USM Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia

[2] Zarqa Univ, Fac Allied Med Sci, Dept Med Lab Sci, Zarqa, Jordan

[3] Hashemite Univ, Fac Appl Med Sci, Dept Med Lab Sci, Zarqa, Jordan

[4] Univ Jordan, Cell Therapy Ctr CTC, Amman, Jordan

[5] Univ Sains Malaysia, Sch Med Sci, Dept Chem Pathol, Kubang Kerian, Malaysia

[6] Univ Sains Malaysia, Sch Med Sci, Dept Microbiol & Parasitol, Kubang Kerian, Malaysia

[7] TardigradeNano LLC, Irvine, CA USA

来源：

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES | 2023年 / 18卷 / 03期

关键词：

2019-nCoV; Convalescent plasma therapy; Coro-navirus; Herd immunity; Reinfection; SARS-CoV-2; CORONAVIRUS DISEASE 2019; CONVALESCENT PLASMA; CHADOX1; NCOV-19; CELLULAR-IMMUNITY; SARS-COV-2; RESPONSES; BNT162B2; RECURRENCE; HOUSEHOLDS; PNEUMONIA;

D O I：

10.1016/j.jtumed.2022.11.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unlike pandemics in the past, the outbreak of coro-navirus disease 2019 (COVID-19), which rapidly spread worldwide, was met with a different approach to control and measures implemented across affected countries. The lack of understanding of the funda-mental nature of the outbreak continues to make COVID-19 challenging to manage for both healthcare practitioners and the scientific community. Challenges to vaccine development and evaluation, current ther-apeutic options, convalescent plasma therapy, herd immunity, and the emergence of reinfection and new variants remain the major obstacles to combating COVID-19. This review discusses these challenges in the management of COVID-19 at length and highlights the mechanisms needed to provide better understand-ing of this pandemic.

引用

页码：600 / 638

页数：39

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