Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis

被引：25

作者：

Shen, Wei ^{[1
,2
,3
,4
,5
]}

Middleton, Michael S. ^{[6
]}

Cunha, Guilherme M. ^{[7
]}

Delgado, Timoteo I. ^{[6
]}

Wolfson, Tanya ^{[8
]}

Gamst, Anthony ^{[8
,9
]}

Fowler, Kathryn J. ^{[6
]}

Alazraki, Adina ^{[10
,11
]}

Trout, Andrew T. ^{[12
,13
]}

Ohliger, Michael A. ^{[14
]}

Shah, Shetal N. ^{[15
,16
]}

Bashir, Mustafa R. ^{[17
,18
,19
]}

Kleiner, David E. ^{[20
]}

Loomba, Rohit ^{[21
]}

Neuschwander-Tetri, Brent A. ^{[22
]}

Sanyal, Arun J. ^{[23
]}

Zhou, Jane ^{[3
]}

Sirlin, Claude B. ^{[6
]}

Lavine, Joel E. ^{[3
,4
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Inst Human Nutr, New York, NY 10032 USA

[3] Columbia Univ, Irving Med Ctr, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, New York, NY USA

[4] Columbia Univ, Irving Med Ctr, Coll Phys & Surg, Inst Human Nutr, New York, NY USA

[5] Columbia Univ, Columbia Magnet Resonance Res Ctr CMRRC, New York, NY USA

[6] UCSD Sch Med, Dept Radiol, Liver Imaging Grp, San Diego, CA USA

[7] Univ Washington, Dept Radiol, Seattle, WA USA

[8] Univ Calif San Diego, San Diego Supercomp Ctr, Computat & Appl Stat Lab CASL, San Diego, CA USA

[9] Univ Calif San Diego, Dept Math, San Diego, CA USA

[10] Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Atlanta, GA USA

[11] Childrens Healthcare Atlanta, Atlanta, GA USA

[12] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Coll Med, Dept Radiol, Cincinnati, OH USA

[13] Univ Cincinnati, Coll Med, Dept Radiol, Cincinnati, OH USA

[14] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[15] Cleveland Clin, Imaging Inst, Sect Abdominal Imaging, Cleveland, OH USA

[16] Cleveland Clin, Imaging Inst, Nucl Med Dept, Cleveland, OH USA

[17] Duke Univ, Med Ctr, Dept Radiol, Durham, NC USA

[18] Duke Univ, Ctr Adv Magnet Resonance Dev, Med Ctr, Dept Radiol, Durham, NC USA

[19] Duke Univ, Dept Med, Div Gastroenterol, Med Ctr, Durham, NC USA

[20] NCI, Lab Pathol, Bethesda, MD USA

[21] Univ Calif San Diego, NAFLD Res Ctr, Dept Med, Div Gastroenterol, La Jolla, CA USA

[22] St Louis Univ, St Louis, MO USA

[23] Virginia Commonwealth Univ, Richmond, VA USA

来源：

JOURNAL OF HEPATOLOGY | 2023年 / 78卷 / 02期

关键词：

central obesity; deep subcutaneous adipose tissue; visceral adipose tissue; liver histology; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR RISK; METABOLIC SYNDROME; INFLAMMATION; ASSOCIATION; FIBROSIS; OBESITY; VOLUME; PREDICTOR;

D O I：

10.1016/j.jhep.2022.10.027

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: Non-alcoholic steatohepatitis (NASH) is prevalent in adults with obesity and can progress to cirrhosis. In a secondary analysis of prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial, we investi-gated the relationship between reduction in adipose tissue compartment volumes and hepatic histologic improvement.Methods: Adult participants in the FLINT trial with paired liver biopsies and abdominal MRI exams at baseline and end-of -treatment (72 weeks) were included (n = 76). Adipose tissue compartment volumes were obtained using MRI.Results: Treatment and placebo groups did not differ in baseline adipose tissue volumes, or in change in adipose tissue volumes longitudinally (p = 0.107 to 0.745). Deep subcutaneous adipose tissue (dSAT) and visceral adipose tissue volume reductions were associated with histologic improvement in NASH (i.e., NAS [non-alcoholic fatty liver disease activity score] reductions of >-2 points, at least 1 point from lobular inflammation and hepatocellular ballooning, and no worsening of fibrosis) (p = 0.031, and 0.030, respectively). In a stepwise logistic regression procedure, which included demographics, treatment group, baseline histology, baseline and changes in adipose tissue volumes, MRI hepatic proton density fat fraction (PDFF), and serum aminotransferases as potential predictors, reductions in dSAT and PDFF were associated with histologic improvement in NASH (regression coefficient =-2.001 and-0.083, p = 0.044 and 0.033, respectively).Conclusions: In adults with NASH in the FLINT trial, those with greater longitudinal reductions in dSAT and potentially visceral adipose tissue volumes showed greater hepatic histologic improvements, independent of reductions in hepatic PDFF.Clinical trial number: NCT01265498.(c) 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：238 / 246

页数：10

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