SNAI1-activated long non-coding RNA LINC01711 promotes hepatic fibrosis cell proliferation and migration by regulating XYLT1

被引：7

作者：

Bao, Linan ^{[1
]}

Chu, Yang ^{[1
]}

Kang, Hui ^{[1
]}

机构：

[1] China Med Univ, Hosp 1, Dept Lab Med, Shenyang 110001, Peoples R China

来源：

GENOMICS | 2023年 / 115卷 / 03期

关键词：

Hepatic fibrosis; Long non-coding RNA (lncRNA); Xylosyltransferase 1 (XYLT1); XYLOSYLTRANSFERASE-I; LIVER FIBROSIS; SERUM XYLOSYLTRANSFERASE; TGF-BETA; MYOFIBROBLASTS; EXPRESSION; MARKER;

D O I：

10.1016/j.ygeno.2023.110597

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Liver fibrosis is the result of the accumulation of extracellular matrix (ECM) that cannot be cleared. Bioinformatic analysis showed that LINC01711 was significantly overexpressed in hepatic fibrosis. The regulatory mechanism of LINC01711 was clarified and confirmed the transcription factors associated with LINC01711. Functionally, LINC01711 promoted LX-2 cell proliferation and migration, indicating that it exerts effects promoting the progression of hepatic fibrosis. Mechanistically, LINC01711 increased the expression of xylosyltransferase 1 (XYLT1), which is an important protein for constructing the ECM. We also confirmed that SNAI1 activated LINC01711 transcription. Taking these findings together, LINC01711 was induced by SNAI1 and promoted the proliferation and migration of LX-2 cells via XYLT1. This study will help to understand the function of LINC01711 and its regulatory mechanism in hepatic fibrosis.

引用

页数：9

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