Antitumor activity of synthetic three copper(II) complexes with terpyridine ligands

被引：12

作者：

Yang, Yang ^{[1
,2
]}

Guo, Fei-Fei ^{[1
]}

Chen, Cai-Feng ^{[1
]}

Li, Yu-Lan

Liang, Hong ^{[1
]}

Chen, Zhen-Feng ^{[1
]}

机构：

[1] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources,Key La, Guilin 541004, Peoples R China

[2] Guilin Normal Coll, Dept Chem & Pharm, Guilin 541199, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2023年 / 240卷

基金：

中国国家自然科学基金;

关键词：

Terpyridine; Copper(II) complex; Crystal structure; Antitumor activity; IN-VITRO; RUTHENIUM(II) COMPLEXES; BIOLOGICAL EVALUATION; MOLECULAR-MECHANISMS; THERMAL-PROPERTIES; DNA; CYTOTOXICITY; PLATINUM; METAL; ELECTROCHEMISTRY;

D O I：

10.1016/j.jinorgbio.2022.112093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new synthetic terpyridine copper(II) complexes were characterized. The copper(II) complexes induced apoptosis of three cancer cell lines and arrested T-24 cell cycle in G1 phase. The complexes were accumulated in mitochondria of T-24 cells and caused significant reduction of the mitochondrial membrane potential. The complexes increased both intracellular ROS and Ca2+ levels and activated the caspase-3/9 expression. The apoptosis was further confirmed by Western Blotting analysis. Bcl-2 was down-regulated and Bax was upregu-lated after treatment with complexes 1-3. The in vivo studies showed that complexes 1-3 obviously inhibited the growth of tumor without significant toxicity to other organs.

引用

页数：12

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