No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

被引：1

作者：

Kim, Yong-Chan ^{[1
,2
,3
]}

Won, Sae-Young ^{[1
,2
,3
]}

Jeong, Byung-Hoon ^{[1
,2
,3
]}

机构：

[1] Jeonbuk Natl Univ, Korea Zoonosis Res Inst, 820-120 Hana Ro, Iksan 820120, Jeonbuk, South Korea

[2] Jeonbuk Natl Univ, Dept Bioact Mat Sci, Jeonju 54896, Jeonbuk, South Korea

[3] Jeonbuk Natl Univ, Inst Mol Biol & Genet, Jeonju 54896, Jeonbuk, South Korea

来源：

MOLECULAR & CELLULAR TOXICOLOGY | 2023年 / 19卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Influenza; Pandemic; PRNP; SNP; Susceptibility; Prion disease; CREUTZFELDT-JAKOB-DISEASE; INFLUENZA; VARIANT;

D O I：

10.1007/s13273-022-00318-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and lethality in influenza A virus-infected mice. Objective Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. Results We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. Conclusions To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.

引用

页码：799 / 803

页数：5

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