Drug Allergy in Children: Adverse Reactions after Skin Testing

被引:0
作者
Karavaizoglu, Cagla [1 ]
Suleyman, Ayse [1 ]
Yavuz Alic, Roza [2 ]
Dolu, Kazim Okan [1 ]
Yucel, Esra [1 ]
Demirkale, Zeynep Hizli [1 ]
Cimen, Sevgi Sipahi [1 ]
Ozdemir, Cevdet [1 ,3 ]
Tamay, Zeynep Ulker [1 ]
机构
[1] Istanbul Univ, Istanbul Fac Med, Dept Pediat, Div Pediat Allergy & Immunol, Istanbul, Turkiye
[2] Istanbul Univ, Istanbul Fac Med, Dept Pediat, Istanbul, Turkiye
[3] Istanbul Univ, Inst Child Hlth, Dept Pediat Basic Sci, Istanbul, Turkiye
关键词
Adverse reaction; Anaphylaxis; Children; Drug skin tests; Safety; SYSTEMIC REACTIONS; HYPERSENSITIVITY; PRICK; IMMUNOTHERAPY; FATALITIES;
D O I
10.1159/000533641
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Introduction: Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the adverse reactions after skin test in children with suspected drug allergy. Methods: Patients who underwent a drug skin test due to the suspicion of drug allergy between May 2017 and June 2020 were evaluated, retrospectively. Data about adverse reactions seen after skin testing at the testing area in the clinic were analyzed. Results: The study included 1,073 children (585 [54.5%] boys and 488 [45.5%] girls) with a median age of 7.5 years. A total of 12 (1.1%) reactions were detected after skin testing, and 4 (0.4%) of them were allergic reactions. Of the allergic reactions, three were anaphylaxis and one was urticaria. Two of the reactions (1 anaphylaxis and 1 urticaria) were detected after the skin prick test and the remaining 2 were detected after intradermal test. Three of the nonallergic reactions were considered as vasovagal reactions and seven were considered as nonspecific and anxiety-related reactions. Conclusion: Although drug skin tests were generally well-tolerated and adverse reactions were rare, severe allergic reactions including anaphylaxis may ensue. Skin tests should be necessarily performed in clinical settings in experienced centers.
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收藏
页码:56 / 62
页数:7
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