The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

被引：149

作者：

Adinolfi, Simone ^{[1
]}

Patinen, Tommi ^{[1
]}

Deen, Ashik Jawahar ^{[1
]}

Pitkänen, Sini

Härkönen, Jouni ^{[2
]}

Kansanen, Emilia ^{[1
,3
]}

Küblbeck, Jenni ^{[1
]}

Levonen, Anna-Liisa ^{[1
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst Mol Sci, POB 1627, FI-70210 Kuopio, Finland

[2] Hosp Nova Cent Finland, Dept Pathol, Jyvaskyla 40620, Finland

[3] Kuopio Univ Hosp, Sci Serv Ctr, Kuopio, Finland

来源：

REDOX BIOLOGY | 2023年 / 63卷

关键词：

NRF2; KEAP1; Cancer; Gene regulation; TRANSCRIPTION FACTOR NRF2; LUNG-CANCER; OXIDATIVE STRESS; ANTIOXIDANT RESPONSE; STRUCTURAL BASIS; GENE; PROTEIN; ACTIVATION; SUBSTRATE; DEGRADATION;

D O I：

10.1016/j.redox.2023.102726

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, motivating research to elucidate the intricacies of NRF2 signaling and its downstream effects to identify novel targets for therapy. In this graphical review, we present an updated overview of the KEAP1-NRF2 signaling, focusing on the progress made within the past ten years. Specifically, we highlight the advances made in understanding the mechanism of activation of NRF2, resulting in novel discoveries in its therapeutic targeting. Furthermore, we will summarize new findings in the rapidly expanding field of NRF2 in cancer, with important implications for its diagnostics and treatment.

引用

页数：10

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