Electrochemical oxidative C(sp3)-H/O-H cross-coupling for the synthesis of α-acyloxyketones

被引：6
作者：
Wu, Jiwei [1 ,2 ]
Shi, Haowen [1 ]
Liu, Jianguo [1 ]
Wang, Ruiyou [1 ]
Zhou, Jie [2 ]
Xu, Xiao-Lan [3 ]
Xu, Hua-Jian [2 ]
机构：
[1] Anhui Sci & Technol Univ, Coll Chem & Mat Engn, Fengyang 233100, Peoples R China
[2] Hefei Univ Technol, Inst Ind & Equipment Technol, Sch Chem & Chem Engn, Sch Food & Biol Engn, Hefei 230009, Peoples R China
[3] Anhui Med Univ, Sch Med Sci, Hefei 230009, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 10期
关键词：
ONE-POT SYNTHESIS; CARBONYL-COMPOUNDS; CARBOXYLIC-ACIDS; KETONES; ACYLOXYLATION; ACETOXYLATION; OXYACYLATION; ACCESS; OXO; FUNCTIONALIZATION;
D O I：
10.1039/d3qo00204g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
C(sp(3))-H/O-H cross-coupling represents an ideal strategy for constructing C(sp(3))-O bonds but remains challenging due to the relatively inert C(sp(3))-H bonds. Herein, we report a facile and novel electrochemical oxidative C(sp(3))-H/O-H cross-coupling method, leading to various useful a-acyloxyketones with moderate to excellent yields under transition metal- and oxidant-free conditions. A series of carboxylic acids including aromatic and aliphatic acids and ketones are compatible with this reaction.
引用
收藏
页码：2459 / 2464
页数：6
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