Oxidative Damage by 3-nitrotyrosine in Young Adults with Obesity: Its Implication in Chronic and Contagious Diseases

Introduction: Cellular damage by oxidation occurs in numerous chronic diseases, such as obesity, type II diabetes, cardiovascular disease, nonalcoholic fatty liver, etc. The oxidized compound 3-nitrotyrosine is a marker of oxidative stress and protein oxidation damage.Objective: The article aims to assess whether 3-nitrotyrosine levels are higher in young people with obesity than in the same population without obesity.Methods: Anthropometry and blood chemistry analyses were performed on 24 young Mexican participants (18-30 years old), categorized into two groups based on their waist circumference: With-obesity (>= 80 cm women; >= 90 cm men) and without-obesity (< 80 cm women; < 90 cm men). Additionally, 3-nitrotyrosine blood values were quantified by ELISA.Results: Except for HDL-cholesterol, the mean values of lipids increased in women and men with obesity (p < 0.05), and 3-nitrotyrosine concentration (nM/mu g total protein) was higher by 60% in the group with-obesity compared to the group without-obesity, both for women (66.21 +/- 23.85 vs. 40.69 +/- 16.25, p < 0.05) and men (51.72 +/- 20.56 vs. 30.52 +/- 5.21, p < 0.05).Conclusion: Oxidative damage measured by compound 3-nitrotyrosine was higher in the group with obesity than in the group without obesity, which, if not controlled, could lead to a chronic oxidative condition and thereby to a degree of cellular aging with adverse health effects.