Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity

被引：3
|
作者：
Xue, Kaili [1 ]
Wu, Dongmei [1 ,2 ]
Qiu, Yifu [1 ,2 ]
机构：
[1] Peking Univ, Coll Future Technol, Inst Mol Med, Beijing Key Lab Cardiometab Mol Med, Beijing 100871, Peoples R China
[2] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
来源：
TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 03期
基金：
国家重点研发计划;
关键词：
BROWN-ADIPOSE-TISSUE; MICE LACKING;
D O I：
10.1016/j.tcb.2022.11.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The mitochondrial calcium uniporter (MCU) controls mitochondrial bio-energetics, and its activity varies greatly between tissues. Here, we highlight a recently identified MCU- EMRE-UCP 1 complex, named thermoporter, in the adaptive ther-mogenesis of brown adipose tissue (BAT). The thermoporter enhances MCU activity to promote thermo-genic metabolism, demonstrating a BAT-specific regulation for MCU activity.
引用
收藏
页码：182 / 184
页数：3
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