Despite being the most common treatment strategy in the management of atherosclerosis and subsequent cardiovascular disease, classical statin therapy has certain disadvantages, including numerous side effects. In addition, a regimen with daily administration of the drug is hard to comply with. Thus, there is a need for modern and more efficient therapeutic strategies in CVD treatment. There is extensive evidence indicating that PCSK9 promotes atherogenesis through a variety of mechanisms. Thus, new treatment methods can be developed that prevent or alleviate atherosclerotic cardiovascular disease by targeting PCSK9. Comprehensive understanding of its atherogenic properties is a necessary precondition for the establishment of new therapeutic strategies. In this review, we will summarize the available data on the role of PCSK9 in the development and progression of atherosclerosis. In the last section, we will consider existing PCSK9 inhibitors.
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Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Miao, Ji
Manthena, Praveen V.
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Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Manthena, Praveen V.
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Haas, Mary E.
Ling, Alisha V.
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Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Ling, Alisha V.
Shin, Dong-Ju
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Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Shin, Dong-Ju
Graham, Mark J.
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ISIS Pharmaceut, Cardiovasc Dis Res, Carlsbad, CA 92008 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Graham, Mark J.
Crooke, Rosanne M.
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ISIS Pharmaceut, Cardiovasc Dis Res, Carlsbad, CA 92008 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Crooke, Rosanne M.
Liu, Jingwen
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VA Palo Alto Healthcare Syst, Dept Vet Affairs, Palo Alto, CA USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Liu, Jingwen
Biddinger, Sudha B.
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Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
机构:
Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Miao, Ji
Manthena, Praveen V.
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机构:
Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Manthena, Praveen V.
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Haas, Mary E.
Ling, Alisha V.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Ling, Alisha V.
Shin, Dong-Ju
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h-index: 0
机构:
Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Shin, Dong-Ju
Graham, Mark J.
论文数: 0引用数: 0
h-index: 0
机构:
ISIS Pharmaceut, Cardiovasc Dis Res, Carlsbad, CA 92008 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Graham, Mark J.
Crooke, Rosanne M.
论文数: 0引用数: 0
h-index: 0
机构:
ISIS Pharmaceut, Cardiovasc Dis Res, Carlsbad, CA 92008 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Crooke, Rosanne M.
Liu, Jingwen
论文数: 0引用数: 0
h-index: 0
机构:
VA Palo Alto Healthcare Syst, Dept Vet Affairs, Palo Alto, CA USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA
Liu, Jingwen
Biddinger, Sudha B.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USAHarvard Univ, Sch Med, Boston Childrens Hosp, Div Endocrinol, Cambridge, MA 02138 USA