Emerging issues on Staphylococcus aureus endocarditis and the role in therapy of daptomycin plus fosfomycin

被引:6
|
作者
Garcia de la Maria, Cristina [1 ]
Canas, Maria-Alexandra [1 ]
Fernandez-Pittol, Mariana [2 ]
Dahl, Anders [1 ,3 ]
Garcia-Gonzalez, Javier [1 ]
Hernandez-Meneses, Marta [1 ]
Cuervo, Guillermo [1 ]
Moreno, Asuncion [1 ]
Miro, Jose M. [1 ,4 ]
Marco, Francesc [2 ,5 ]
机构
[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Infect Dis Serv, Barcelona, Spain
[2] Hosp Clin Barcelona, Microbiol Dept, Ctr Diagnost Biomed, Barcelona, Spain
[3] Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark
[4] Inst Salud Carlos III, CIBERINFEC, Madrid, Spain
[5] Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
关键词
Methicillin-sensitive Staphylococcus aureus; methicillin-resistant Staphylococcus aureus; daptomycin; fosfomycin; synergy; combined therapy; bactericidal activity; infective endocarditis; METHICILLIN-RESISTANT; INFECTIVE ENDOCARDITIS; PERSISTENT BACTEREMIA; CLINICAL PRESENTATION; NEUTROPHIL DEFENSIN; CELL-MEMBRANE; BETA-LACTAMS; SUSCEPTIBILITY; VANCOMYCIN; LIPOPEPTIDE;
D O I
10.1080/14787210.2023.2174969
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
IntroductionMethicillin-resistant and -susceptible Staphylococcus aureus (MRSA/MSSA) infections are a major global health-care problem. Bacteremia with S. aureus exhibits high rates of morbidity and mortality and can cause complicated infections such as infective endocarditis (IE). The emerging resistance profile of S. aureus is worrisome, and several international agencies have appealed for new treatment approaches to be developed.Areas coveredDaptomycin presents a rapid bactericidal effect against MRSA and has been considered at least as effective as vancomycin in treating MRSA bacteremia. However, therapy failure is often related to deep-seated infections, e.g. endocarditis, with high bacterial inocula and daptomycin regimens S. aureus infections have limitations in monotherapy. Daptomycin in combination with other antibiotics, e.g. fosfomycin, may be effective in improving clinical outcomes in patients with MRSA IE.Expert opinionExploring therapeutic combinations has shown fosfomycin to have a unique mechanism of action and to be the most effective option in preventing the onset of resistance to and optimizing the efficacy of daptomycin, suggesting the synergistic combination of fosfomycin with daptomycin is a useful alternative treatment option for MSSA or MRSA IE.
引用
收藏
页码:281 / 293
页数:13
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