Emerging issues on Staphylococcus aureus endocarditis and the role in therapy of daptomycin plus fosfomycin

被引:6
|
作者
Garcia de la Maria, Cristina [1 ]
Canas, Maria-Alexandra [1 ]
Fernandez-Pittol, Mariana [2 ]
Dahl, Anders [1 ,3 ]
Garcia-Gonzalez, Javier [1 ]
Hernandez-Meneses, Marta [1 ]
Cuervo, Guillermo [1 ]
Moreno, Asuncion [1 ]
Miro, Jose M. [1 ,4 ]
Marco, Francesc [2 ,5 ]
机构
[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Infect Dis Serv, Barcelona, Spain
[2] Hosp Clin Barcelona, Microbiol Dept, Ctr Diagnost Biomed, Barcelona, Spain
[3] Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark
[4] Inst Salud Carlos III, CIBERINFEC, Madrid, Spain
[5] Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
关键词
Methicillin-sensitive Staphylococcus aureus; methicillin-resistant Staphylococcus aureus; daptomycin; fosfomycin; synergy; combined therapy; bactericidal activity; infective endocarditis; METHICILLIN-RESISTANT; INFECTIVE ENDOCARDITIS; PERSISTENT BACTEREMIA; CLINICAL PRESENTATION; NEUTROPHIL DEFENSIN; CELL-MEMBRANE; BETA-LACTAMS; SUSCEPTIBILITY; VANCOMYCIN; LIPOPEPTIDE;
D O I
10.1080/14787210.2023.2174969
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
IntroductionMethicillin-resistant and -susceptible Staphylococcus aureus (MRSA/MSSA) infections are a major global health-care problem. Bacteremia with S. aureus exhibits high rates of morbidity and mortality and can cause complicated infections such as infective endocarditis (IE). The emerging resistance profile of S. aureus is worrisome, and several international agencies have appealed for new treatment approaches to be developed.Areas coveredDaptomycin presents a rapid bactericidal effect against MRSA and has been considered at least as effective as vancomycin in treating MRSA bacteremia. However, therapy failure is often related to deep-seated infections, e.g. endocarditis, with high bacterial inocula and daptomycin regimens S. aureus infections have limitations in monotherapy. Daptomycin in combination with other antibiotics, e.g. fosfomycin, may be effective in improving clinical outcomes in patients with MRSA IE.Expert opinionExploring therapeutic combinations has shown fosfomycin to have a unique mechanism of action and to be the most effective option in preventing the onset of resistance to and optimizing the efficacy of daptomycin, suggesting the synergistic combination of fosfomycin with daptomycin is a useful alternative treatment option for MSSA or MRSA IE.
引用
收藏
页码:281 / 293
页数:13
相关论文
共 50 条
  • [21] Efficacy of daptomycin in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Sakoulas, G
    Eliopoulos, GM
    Alder, J
    Thauvin-Eliopoulos, C
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (05) : 1714 - 1718
  • [22] Daptomycin experience for Staphylococcus aureus left-sided endocarditis from a registry
    Levine, D. P.
    Lamp, K. C.
    CLINICAL RESEARCH IN CARDIOLOGY, 2007, 96 (06) : 426 - 426
  • [23] Assessment of invitrosynergy of daptomycin or vancomycin plus ceftaroline for daptomycin non-susceptible Staphylococcus aureus
    Hutton, Mary A.
    Sundaram, Ayesha
    Perri, Mary B.
    Zervos, Marcus J.
    Herc, Erica S.
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2020, 98 (03)
  • [24] Development of daptomycin resistance during therapy in a patient with methicillin-resistant Staphylococcus aureus endocarditis: A case report
    Sotillo, Alma
    Ramon Pano-Pardo, Jose
    Lopez-Quintana, Beatriz
    Gomez-Gil, Rosa
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2016, 34 (08): : 534 - 535
  • [25] ANTIMICROBIAL THERAPY OF STAPHYLOCOCCUS-AUREUS ENDOCARDITIS
    BAIRD, IM
    WATANAKUNAKORN, C
    CLINICAL RESEARCH, 1975, 23 (04): : A531 - A531
  • [26] NAFCILLIN THERAPY FOR STAPHYLOCOCCUS-AUREUS ENDOCARDITIS
    MASUR, H
    MURRAY, HW
    ROBERTS, RB
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 14 (03) : 457 - 461
  • [27] Role of monocytes in experimental Staphylococcus aureus endocarditis
    Veltrop, MHAM
    Bancsi, MJLMF
    Bertina, RM
    Thompson, J
    INFECTION AND IMMUNITY, 2000, 68 (08) : 4818 - 4821
  • [28] The Combination of Daptomycin and Fosfomycin Has Synergistic, Potent, and Rapid Bactericidal Activity against Methicillin-Resistant Staphylococcus aureus in a Rabbit Model of Experimental Endocarditis
    Garcia-de-la-Maria, Cristina
    Gasch, Oriol
    Garcia-Gonzalez, Javier
    Soy, Dolors
    Shaw, Evelyn
    Ambrosioni, Juan
    Almela, Manel
    Pericas, Juan M.
    Tellez, Adrian
    Falces, Carlos
    Hernandez-Meneses, Marta
    Sandoval, Elena
    Quintana, Eduard
    Vidal, Barbara
    Tolosana, Jose M.
    Fuster, David
    Llopis, Jaume
    Pujol, Miquel
    Moreno, Asuncion
    Marco, Francesc
    Miro, Jose M.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (06)
  • [29] Effectiveness and safety of fosfomycin plus imipenem as rescue therapy for bacteremia and endocarditis due to methicillin-resistant Staphylococcus aureus: A multi-center clinical trial
    Botelho-Nevers, E.
    MEDECINE ET MALADIES INFECTIEUSES, 2015, 45 (1-2): : 63 - 64
  • [30] Successful treatment of meticillin-resistant Staphylococcus aureus (MRSA) aortic prosthetic valve endocarditis with prolonged high-dose daptomycin plus ceftaroline therapy
    Cunha, Burke A.
    Gran, Arthur
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2015, 46 (02) : 225 - 226