Harnessing the potential of long non-coding RNAs in breast cancer: from etiology to treatment resistance and clinical applications

被引:2
作者
Wang, Yun [1 ]
Bu, Na [1 ]
Luan, Xiao-fei [1 ]
Song, Qian-qian [1 ]
Ma, Ba-Fang [2 ]
Hao, Wenhui [3 ]
Yan, Jing-jing [1 ]
Wang, Li [1 ]
Zheng, Xiao-ling [1 ]
Maimaitiyiming, Yasen [2 ,4 ,5 ,6 ,7 ]
机构
[1] Zhejiang Univ, Womens Hosp, Dept Pharm, Sch Med, Hangzhou, Peoples R China
[2] Xinjiang Med Univ, Sch Basic Med Sci, Dept Immunol, Urumqi, Peoples R China
[3] Xinjiang Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Urumqi, Xinjiang, Peoples R China
[4] Zhejiang Univ, Canc Ctr, Sch Med, Hangzhou, Peoples R China
[5] Zhejiang Univ, Womens Hosp, Inst Genet, Sch Med, Hangzhou, Peoples R China
[6] Zhejiang Univ, Sch Med, Dept Environm Med, Hangzhou, Peoples R China
[7] Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hig, Urumqi, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
基金
中国国家自然科学基金;
关键词
breast cancer; metastasis; therapy resistance; long non-coding RNA (LncRNA); competitive endogenous RNA (ceRNA); liquid biopsy; ENHANCES TAMOXIFEN RESISTANCE; CELL-PROLIFERATION; STEM-CELLS; TRASTUZUMAB RESISTANCE; DOXORUBICIN RESISTANCE; MCF-7; CELLS; LNCRNA; METASTASIS; PROMOTES; HOTAIR;
D O I
10.3389/fonc.2024.1337579
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer (BC) is the most common malignancy among women and a leading cause of cancer-related deaths of females worldwide. It is a complex and molecularly heterogeneous disease, with various subtypes that require different treatment strategies. Despite advances in high-resolution single-cell and multinomial technologies, distant metastasis and therapeutic resistance remain major challenges for BC treatment. Long non-coding RNAs (lncRNAs) are non-coding RNAs with more than 200 nucleotides in length. They act as competing endogenous RNAs (ceRNAs) to regulate post-transcriptional gene stability and modulate protein-protein, protein-DNA, and protein-RNA interactions to regulate various biological processes. Emerging evidence suggests that lncRNAs play essential roles in human cancers, including BC. In this review, we focus on the roles and mechanisms of lncRNAs in BC progression, metastasis, and treatment resistance, and discuss their potential value as therapeutic targets. Specifically, we summarize how lncRNAs are involved in the initiation and progression of BC, as well as their roles in metastasis and the development of therapeutic resistance. We also recapitulate the potential of lncRNAs as diagnostic biomarkers and discuss their potential use in personalized medicine. Finally, we provide lncRNA-based strategies to promote the prognosis of breast cancer patients in clinical settings, including the development of novel lncRNA-targeted therapies.
引用
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页数:17
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