A novel FA1-targeting fluorescent probe for specific discrimination and identification of human serum albumin from bovine serum albumin

被引：7

作者：

Huyan, Yuchen ^{[1
]}

Nan, Xiaojing ^{[1
]}

Li, Hongjuan ^{[1
]}

Sun, Shiguo ^{[1
]}

Xu, Yongqian ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Chem & Pharm, Yangling, Shaanxi, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 28期

基金：

中国国家自然科学基金;

关键词：

Amino acids - Fluorescence - Hydrogen bonds - Mammals - Probes - Surface plasmon resonance;

D O I：

10.1039/d4cc00407h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel probe C1 combining benzothiazole with a spiropyran section was developed for the specific detection of human serum albumin (HSA). The molecular docking suggested that the sulphonic acid group modification allowed C1 to form specific hydrogen bonds with lysine (Lys137) at fatty acid site 1 (FA1) of HSA, thus enabling fluorescence differentiation between HSA and BSA. A novel probe C1 combining benzothiazole with a spiropyran section was developed for the specific detection of human serum albumin (HSA).

引用

页码：3810 / 3813

页数：4

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