Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease

被引：3

作者：

Tagami, Yoichi ^{[1
]}

Hara, Yu ^{[1
]}

Murohashi, Kota ^{[1
]}

Nagasawa, Ryo ^{[1
]}

Fujii, Hiroaki ^{[1
]}

Izawa, Ami ^{[1
]}

Yabe, Aya ^{[1
]}

Saigusa, Yusuke ^{[2
]}

Kobayashi, Miyu ^{[2
]}

Shiida, Masafumi ^{[3
]}

Hirata, Momo ^{[1
]}

Otsu, Yukiko ^{[1
]}

Watanabe, Keisuke ^{[1
]}

Horita, Nobuyuki ^{[1
]}

Kobayashi, Nobuaki ^{[1
]}

Kaneko, Takeshi ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Pulmonol, 3-9 Fukuura,Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Biostat, Yokohama, Japan

[3] Minaris Med Co, Res & Dev Div, 600-1 Minami Ishiki, Nagaizumi, Shizuoka 4110932, Japan

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; SUPEROXIDE-DISMUTASE; DIAGNOSTIC UTILITY; OXIDATIVE STRESS; TGF-BETA; HEMEOXYGENASE-1; EXPRESSION; PNEUMONIA; CATALASE;

D O I：

10.1038/s41598-023-49342-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Serum heme oxygenase (HO)-1 level has been reported as a clinically reliable diagnostic biomarker for acute exacerbation of interstitial lung disease (ILD); however, its utility for predicting mortality among these patients is unclear. Serum HO-1 levels of patients newly diagnosed with acute exacerbation of ILD were measured at the time of initiating steroid pulse therapy. The relationship between serum HO-1 and various other serum biomarkers, change in HRCT findings, and disease prognosis at 12 weeks after diagnosis of acute exacerbation was evaluated in 51 patients, of whom 17 (33%) had idiopathic pulmonary fibrosis (IPF). Serum HO-1 was higher in patients with acute exacerbation of IPF than in patients with acute exacerbation of other ILDs. Serum HO-1 levels were higher in patients who died within these 12 weeks than in survivors. Among age, sex, comorbidities, IPF diagnosis, HRCT findings, and blood biomarkers, serum HO-1 was a primary predictor of 12-week mortality. In 41 patients who underwent repeat HRCT, serum HO-1 was higher in patients with honeycomb progression than in those without. Serum HO-1 measurement could be useful for evaluating disease mortality and morbidity of patients with acute exacerbation of ILDs.

引用

页数：9

共 48 条

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