Exosomal MicroRNAs: An Emerging Important Regulator in Acute Lung Injury

被引:9
作者
Lan, Bowen [1 ,2 ]
Dong, Xuanchi [1 ,2 ]
Yang, Qi [1 ,2 ,3 ]
Luo, Yalan [1 ,2 ,4 ]
Wen, Haiyun [1 ,2 ,4 ]
Chen, Zhe [1 ,2 ]
Chen, Hailong [1 ,2 ,4 ]
机构
[1] Dalian Med Univ, Dept Anorectal Surg, Affiliated Hosp 1, Dalian 116000, Peoples R China
[2] Dalian Med Univ, Lab Integrat Med, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China
[3] Dalian Med Univ, Affiliated Hosp 2, Dept Tradit Chinese Med, Dalian 116023, Peoples R China
[4] Dalian Med Univ, Inst Coll Integrat Med, Dalian 116044, Peoples R China
来源
ACS OMEGA | 2023年 / 8卷 / 39期
基金
中国国家自然科学基金;
关键词
ACUTE RESPIRATORY-DISTRESS; ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; RETICULOCYTES IN-VITRO; TRANSFERRIN RECEPTOR; SELECTIVE EXTERNALIZATION; DENDRITIC CELLS; PLASMA EXOSOME; CANCER; BIOMARKERS;
D O I
10.1021/acsomega.3c04955
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Acute lung injury (ALI) is a clinically life-threatening form of respiratory failure with a mortality of 30%-40%. Acute respiratory distress syndrome is the aggravated form of ALI. Exosomes are extracellular lipid vesicles ubiquitous in human biofluids with a diameter of 30-150 nm. They can serve as carriers to convey their internal cargo, particularly microRNA (miRNA), to the target cells involved in cellular communication. In disease states, the quantities of exosomes and the cargo generated by cells are altered. These exosomes subsequently function as autocrine or paracrine signals to nearby or distant cells, regulating various pathogenic processes. Moreover, exosomal miRNAs from multiple stem cells can provide therapeutic value for ALI by regulating different signaling pathways. In addition, changes in exosomal miRNAs of biofluids can serve as biomarkers for the early diagnosis of ALI. This study aimed to review the role of exosomal miRNAs produced by different sources participating in various pathological processes of ALI and explore their potential significance in the treatment and diagnosis.
引用
收藏
页码:35523 / 35537
页数:15
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