Physical similarity simulation is one of the best methods for improving coal bed methane extraction efficiency, and the development of reasonable materials is important for improving physical similarity simulation testing results. This study aimed to investigate the mechanical properties of coal-like materials in a solid-gas coupled physical simulation test experiment. A new type of material with sand as aggregate, cement gypsum as cement, and silica gel as adsorbent was developed by an orthogonal design method. ANOVA and theoretical analysis were used to investigate the sensitivity and effects of different content ratios on the volumetric weight, uniaxial compressive strength, and elastic modulus of coal-like materials. The results of the investigation showed that the order of volumetric weight sensitivity ranging from large to small was the contents of silica gel, gypsum, and cement. The order of the sensitivity of uniaxial compressive strength and elastic modulus ranging from large to small was the ratio of the contents of silica gel, cement, and gypsum. Furthermore, the volumetric weight, uniaxial compressive strength, and elastic modulus of coal-like materials increased linearly and exponentially with the increase of cement and gypsum contents, respectively, whereas they decreased exponentially with the increase of silica content. Based on the results and analysis, a comprehensive model for the characteristic parameters of coal-like materials was established, and the prediction error was controllable to within 25%.