The Blood Contents of Pro-Inflammatory Chemokines in Patients with a First Episode of Schizophrenia before Therapy

被引：1
作者：
Sakharov, A. V. [1 ]
Golygina, S. E. [1 ]
Prokhorov, A. S. [1 ]
Tereshkov, P. P. [1 ]
机构：
[1] Chita State Med Acad, Chita, Russia
来源：
NEUROCHEMICAL JOURNAL | 2023年 / 17卷 / 01期
关键词：
neuroinflammation; schizophrenia; first psychotic episode; chemokines; CENTRAL-NERVOUS-SYSTEM; CELL-DERIVED FACTOR-1/CXCL12; RECEPTOR CXCR3; EXPRESSION; ACTIVATION; ASTROCYTES; HYPOTHESIS; MICROGLIA; RELEVANCE; NEURONS;
D O I：
10.1134/S1819712423010178
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The role of chemokines involved in the processes of neuroinflammation is not well understood in schizophrenia, especially in patients with the first episode of the disease. The aim of this research was to study the contents of pro-inflammatory chemokines in the blood of patients with the first episode of paranoid schizophrenia. We examined 18 patients with a diagnosis of F20.09, the control group was 35 people. Determination of the contents of 13 chemokines in the blood serum was carried out by flow fluorometry. Blood sampling was carried out before the start of therapy. In patients with the first episode of schizophrenia before the appointment of therapy, we found an increase in the blood level of CCL4 (MIP-1 beta) by 1.1 times; CXCL9 (MIG) by 1.4 times; CCL11 (Eotaxin), CXCL5 (ENA-78), and CXCL10 (IP-10) by 1.5 times; CXCL1 (GRO-alpha) by 1.6 times; CCL20 (MIP-3 alpha) by 2.1 times; and CXCL8 (IL-8) by 21.0 times. The results we obtained indicate the importance of neuroimmune inflammation in the manifestation of schizophrenia with the involvement of chemokines in this process.
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页码：138 / 142
页数：5
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