AXL in cancer: a modulator of drug resistance and therapeutic target

被引：53
作者：
Tang, Yaoxiang [1 ]
Zang, Hongjing [1 ]
Wen, Qiuyuan [1 ]
Fan, Songqing [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Pathol, Changsha 410011, Hunan, Peoples R China
来源：
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2023年 / 42卷 / 01期
基金：
中国国家自然科学基金;
关键词：
AXL; Cancer; Drug resistance; Target therapy; Molecular mechanisms; RECEPTOR TYROSINE KINASE; EPITHELIAL-MESENCHYMAL TRANSITION; CELL LUNG-CANCER; ACQUIRED-RESISTANCE; BREAST-CANCER; DNA-DAMAGE; GAS6/AXL AXIS; EGFR-TKI; INHIBITION; PROMOTES;
D O I：
10.1186/s13046-023-02726-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
AXL is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family (RTKs), and its abnormal expression has been linked to clinicopathological features and poor prognosis of cancer patients. There is mounting evidence supporting AXL's role in the occurrence and progression of cancer, as well as drug resistance and treatment tolerance. Recent studies revealed that reducing AXL expression can weaken cancer cells' drug resistance, indicating that AXL may be a promising target for anti-cancer drug treatment. This review aims to summarize the AXL's structure, the mechanisms regulating and activating it, and its expression pattern, especially in drug-resistant cancers. Additionally, we will discuss the diverse functions of AXL in mediating cancer drug resistance and the potential of AXL inhibitors in cancer treatment.
引用
收藏
页数：14
相关论文
共 113 条
[11]   Tissue Microarray Analyses Suggest Axl as a Predictive Biomarker in HPV-Negative Head and Neck Cancer [J].
Busch, Chia-Jung ;
Hagel, Christian ;
Becker, Benjamin ;
Oetting, Agnes ;
Moeckelmann, Nikolaus ;
Droste, Conrad ;
Moeller-Koop, Christina ;
Witt, Melanie ;
Blaurock, Markus ;
Loges, Sonja ;
Rothkamm, Kai ;
Betz, Christian ;
Muenscher, Adrian ;
Clauditz, Till S. ;
Rieckmann, Thorsten .
CANCERS, 2022, 14 (07)
[12]   Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer [J].
Cabanos, Heidie Frisco ;
Hata, Aaron N. .
CANCERS, 2021, 13 (11)
[13]   AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer [J].
Cardone, Claudia ;
Blauensteiner, Bernadette ;
Moreno-Viedma, Veronica ;
Martini, Giulia ;
Simeon, Vittorio ;
Vitiello, Pietro P. ;
Ciardiello, Davide ;
Belli, Valentina ;
Matrone, Nunzia ;
Troiani, Teresa ;
Morgillo, Floriana ;
Marino, Federica Zito ;
Dentice, Monica ;
Nappi, Annarita ;
Boccaccino, Alessandra ;
Antoniotti, Carlotta ;
Cremolini, Chiara ;
Pietrantonio, Filippo ;
Prager, Gerald W. ;
Normanno, Nicola ;
Maiello, Evaristo ;
Argiles, Guillem ;
Elez, Elena ;
Signoriello, Giuseppe ;
Franco, Renato ;
Falcone, Alfredo ;
Tabernero, Josep ;
Sibilia, Maria ;
Ciardiello, Fortunato ;
Martinelli, Erika .
EUROPEAN JOURNAL OF CANCER, 2020, 138 :1-10
[14]   Targeting Axl With an High-affinity Inhibitory Aptamer [J].
Cerchia, Laura ;
Esposito, Carla L. ;
Camorani, Simona ;
Rienzo, Anna ;
Stasio, Loredana ;
Insabato, Luigi ;
Affuso, Andrea ;
de Franciscis, Vittorio .
MOLECULAR THERAPY, 2012, 20 (12) :2291-2303
[15]   Polytherapy and Targeted Cancer Drug Resistance [J].
Chatterjee, Nilanjana ;
Bivona, Trever G. .
TRENDS IN CANCER, 2019, 5 (03) :170-182
[16]   Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL [J].
Chen, Yingshi ;
Zhang, Yiwen ;
Chen, Siqi ;
Liu, Weiwei ;
Lin, Yingtong ;
Zhang, Hui ;
Yu, Fei .
PIGMENT CELL & MELANOMA RESEARCH, 2022, 35 (02) :238-251
[17]   Engineering Axl specific CAR and SynNotch receptor for cancer therapy [J].
Cho, Jang Hwan ;
Okuma, Atsushi ;
Al-Rubaye, Dalal ;
Intisar, Ejaj ;
Junghans, Richard P. ;
Wong, Wilson W. .
SCIENTIFIC REPORTS, 2018, 8
[18]   Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance [J].
D'Errico, Gabriele ;
Alonso-Nocelo, Marta ;
Vallespinos, Mireia ;
Hermann, Patrick C. ;
Alcala, Sonia ;
Pedrero Garcia, Coral ;
Martin-Hijano, Laura ;
Valle, Sandra ;
Earl, Julie ;
Cassiano, Chiara ;
Lombardia, Luis ;
Feliu, Jaime ;
Monti, Maria Chiara ;
Seufferlein, Thomas ;
Garcia-Bermejo, Laura ;
Martinelli, Paola ;
Carrato, Alfredo ;
Sainz, Bruno, Jr. .
ONCOGENE, 2019, 38 (27) :5469-5485
[19]   Post-Surgery Circulating Tumor Cells and AXL Overexpression as New Poor Prognostic Biomarkers in Resected Lung Adenocarcinoma [J].
de Miguel-Perez, Diego ;
Isabel Bayarri-Lara, Clara ;
Gabriel Ortega, Francisco ;
Russo, Alessandro ;
Moyano Rodriguez, Maria Jose ;
Jesus Alvarez-Cubero, Maria ;
Maza Serrano, Elizabeth ;
Antonio Lorente, Jose ;
Rolfo, Christian ;
Jose Serrano, Maria .
CANCERS, 2019, 11 (11)
[20]   Therapeutic aspects of the Axl/Gas6 molecular system [J].
Di Stasi, Rossella ;
De Rosa, Lucia ;
D'Andrea, Luca D. .
DRUG DISCOVERY TODAY, 2020, 25 (12) :2130-2148
12345678910