Design and Statistical Optimization of Pluronic Based Ibuprofen Gels by Box-Behnken Design and Their Physicochemical Characterization

被引：0

作者：

Avasarala, Harani ^{[1
]}

Kumar, D. Sathis ^{[2
]}

Tripathy, Srijit ^{[2
]}

Sravani, Sathi ^{[2
]}

Devi, Veera Vimala ^{[2
]}

Kamaluddin, Shaike ^{[2
]}

机构：

[1] Aditya Coll Pharm, Surampalem, Andhra Pradesh, India

[2] Aditya Pharm Coll, Surampalem, Andhra Pradesh, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2023年 / 57卷 / 01期

关键词：

ibuprofen; pluronic base; Box-Behnken design; optimization; in vitro diffusion; IN-VITRO; POLOXAMER; DELIVERY;

D O I：

10.1007/s11094-023-02860-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present work was focused on the development of pluronic based ibuprofen gels for the purpose of increasing drug solubility with the aid of pluronic F127, pluronic L64, and propylene glycol additives as gelling agents and central composite design (CCD) expert software for optimizing their percentage content. The desired gels were formulated and evaluated for the gelation temperature and drug content as analyzed by the CCD expert software. Finally optimized gel formulations (OFs) were subjected to in vitro diffusion studies in terms of a kinetic fitting model. It was found that OF1 had the optimum concentrations in making effective pluronic based ibuprofen gels with desired response characteristics. Pluronic gels can be used as efficient means of formulation to enhance drug solubility and permeability which is confirmed by the results of in vitro diffusion studies and flux calculations.

引用

页码：129 / 137

页数：9

共 25 条

[1]

ADAMS SS, 1969, ARCH INT PHARMACOD T, V178, P115

[2] Sustained Delivery of IL-1Ra from Pluronic F127-Based Thermosensitive Gel Prolongs its Therapeutic Potentials [J].

Akash, Muhammad Sajid Hamid ;

Rehman, Kanwal ;

Li, Ni ;

Gao, Jian-Qing ;

Sun, Hongying ;

Chen, Shuqing .

PHARMACEUTICAL RESEARCH, 2012, 29 (12) :3475-3485

[3]

[Anonymous], 2014, Int J Adv Pharm Gen Res

[4]

[Anonymous], 2006, ENCY PHARM TECHNOLOG, V3, P1875

[5]

[Anonymous], 2007, INDIAN PHARMACOPOEIA

[6]

Aulton M.E., 2007, AULTONS PHARM DESIGN, V3rd

[7] Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base [J].

Baloglu, Esra ;

Karavana, Sinem Yaprak ;

Senyigit, Zeynep Ay ;

Guneri, Tamer .

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2011, 16 (06) :627-636

[8] In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation [J].

Baloglu, Esra ;

Karavana, Sinem Yaprak ;

Senyigit, Zeynep Ay ;

Hilmioglu-Polat, Suleyha ;

Metin, Dilek Yesim ;

Zekioglu, Osman ;

Guneri, Tamer ;

Jones, David S. .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63 (10) :1274-1282

[9]

Bushra R., 2010, MED J, V25, P155

[10]

Chime Salome A., 2013, Res. J. Pharm. Biol. Chem. Sci, V4, P97

← 1 2 3 →