ZnSe-based highly-sensitive SPR biosensor for detection of different cancer cells and urine glucose levels

被引：30

作者：

El-assar, Mohamed ^{[1
]}

Taha, Taha E. ^{[1
]}

Abd El-Samie, Fathi E. ^{[1
]}

Fayed, Heba A. ^{[2
]}

Aly, Moustafa H. ^{[2
]}

机构：

[1] Menoufia Univ, Fac Elect Engn, Dept Elect & Elect Commun Engn, Menoufia, Egypt

[2] Arab Acad Sci Technol & Maritime Transport, Coll Engn & Technol, Elect & Commun Engn Dept, Alexandria, Egypt

来源：

OPTICAL AND QUANTUM ELECTRONICS | 2023年 / 55卷 / 01期

关键词：

Surface plasmon resonance (SPR); Biosensors; Cancer cell detection; Glucose level detection; ZnSe; SURFACE-PLASMON RESONANCE; NUMERICAL-ANALYSIS; SAMPLES; DESIGN;

D O I：

10.1007/s11082-022-04326-y

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

As detection of cancer and diabetes diseases has captured a great attention in the field of biosensing, many ways were introduced to detect these diseases with high accuracy. This paper presents a novel use of zinc selenide (ZnSe) semiconductor material to enhance the sensitivity of a conventional Ag-based surface plasmon resonance biosensor. The proposed sensor structure is simple (BK7 prism/Ag/ZnSe), cost-effective, and easy to design and fabricate. The sensor is tested in the detection of different cancerous cells in human blood, showing an excellent sensitivity of 359 degrees/RIU. In addiion, it is tested to detect various glucose levels in human urine, and it provides a very high performance with a sensitivity of 366.6 degrees/RIU, which is 70% better than that of a similar reported work. Thus, the proposed biosensor is capable efficiently to detect various kinds of cancer cells and different glucose concentrations in urine.

引用

页数：16

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