Short, frequent, light-intensity walking activity improves postprandial vascular-inflammatory biomarkers in people with type 1 diabetes: The SIT-LESS randomized controlled trial

被引：0

作者：

Safdar, Nawaz Z. ^{[1
,2
]}

Alobaid, Anwar M. ^{[3
,4
]}

Hopkins, Mark ^{[3
]}

Dempsey, Paddy C. ^{[5
,6
,7
,8
]}

Pearson, Sam M. ^{[1
]}

Kietsiriroje, Noppadol ^{[1
,9
]}

Churm, Rachel ^{[10
]}

Ajjan, Ramzi A. ^{[1
]}

Campbell, Matthew D. ^{[1
,5
,11
,12
]}

机构：

[1] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Fac Med, Leeds, England

[2] St James Univ Hosp, Leeds Teaching Hosp NHS Trust, Dept Internal Med, Leeds, England

[3] Univ Leeds, Fac Environm, Sch Food Sci & Nutr, Leeds, England

[4] Farwaniya Hosp, Minist Hlth, Kuwait, Kuwait

[5] Univ Cambridge, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England

[6] Univ Leicester, Leicester Gen Hosp, Diabet Res Ctr, Leicester, England

[7] Baker Heart & Diabet Inst, Melbourne, Vic, Australia

[8] Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong, Vic, Australia

[9] Prince Songkla Univ, Fac Med, Endocrinol & Metab Unit, Hat Yai, Thailand

[10] Swansea Univ, Fac Sci & Engn, Exercise & Med A STEM Res Ctr, Appl Sports Technol, Swansea, Wales

[11] Univ Sunderland, John Dawson Drug Discovery & Dev Inst, Sunderland, England

[12] Univ Sunderland, John Dawson Drug Discovery & Dev Inst, Fac Hlth Sci & Wellbeing, Sunderland, England

来源：

DIABETES OBESITY & METABOLISM | 2024年 / 26卷 / 06期

关键词：

inflammation; physical activity; sedentariness; thrombosis; type; 1; diabetes; INSULIN; ADULTS; RESISTANCE; EXERCISE;

D O I：

10.1111/dom.15564

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim To examine the effect of interrupting prolonged sitting with short, frequent, light-intensity activity on postprandial cardiovascular markers in people with type 1 diabetes (T1D). Materials and Methods In a randomized crossover trial, 32 adults with T1D (mean +/- SD age 28 +/- 5 years, glycated haemoglobin 67.9 +/- 12.6 mmol/mol, 17 women) completed two 7-h laboratory visits separated by >7 days. Participants either remained seated for 7 h (SIT) or interrupted sitting with 3-min bouts of self-paced walking at 30-min intervals commencing 1 h after each meal (SIT-LESS). Physical activity, insulin regimen, experimental start times, and meal consumption were standardized during each arm. Plasma levels of interleukin (IL)-1 beta, tumour necrosis factor (TNF)-alpha, plasminogen activator inhibitor (PAI)-1 and fibrinogen were sampled at baseline, 3.5 and 7 h, and assessed for within- and between-group effects using a repeated measures ANOVA. The estimated glucose disposal rate was used to determine the insulin resistance status. Results Vascular-inflammatory parameters were comparable between SIT and SIT-LESS at baseline (p > .05). TNF-alpha, IL-1 beta, PAI-1 and fibrinogen increased over time under SIT, whereas these rises were attenuated under SIT-LESS (p < .001). Specifically, over the 7 h under SIT, postprandial increases were detected in TNF-alpha, IL-1 beta, PAI-1 and fibrinogen (+67%, +49%, +49% and +62%, respectively; p < .001 for all). Conversely, the SIT-LESS group showed no change in IL-1 beta (-9%; p > .50), whereas reductions were observed in TNF-alpha, PAI-1 and fibrinogen (-22%, -42% and -44%, respectively; p < .001 for all). The intervention showed enhanced effects in insulin-resistant individuals with T1D. Conclusions Interrupting prolonged sitting with light-intensity activity ameliorates postprandial increases in vascular-inflammatory markers in T1D.

引用

页码：2439 / 2445

页数：7

共 1 条

[1] Interrupting prolonged sitting with frequent short bouts of light-intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The SIT-LESS randomised controlled trial
Campbell, Matthew D.
Alobaid, Anwar M.
Hopkins, Mark
Dempsey, Paddy C.
Pearson, Sam M.
Kietsiriroje, Noppadol
Churm, Rachel
Ajjan, Ramzi A.
DIABETES OBESITY & METABOLISM, 2023, 25 (12) : 3589 - 3598

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