Integrated control of bacterial growth and stress response by (p)ppGpp in Escherichia coli: A seesaw fashion

被引：9

作者：

Zhu, Manlu ^{[1
,2
]}

Mu, Haoyan ^{[1
,2
]}

Dai, Xiongfeng ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Sch Life Sci, Wuhan, Peoples R China

[2] Cent China Normal Univ, Natl Key Lab Green Pesticides, Wuhan, Peoples R China

来源：

ISCIENCE | 2024年 / 27卷 / 02期

基金：

中国国家自然科学基金;

关键词：

GENE-EXPRESSION; PPGPP; PROTEIN; FAMINE; TRANSCRIPTION; FEAST;

D O I：

10.1016/j.isci.2024.108818

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To thrive in nature, bacteria have to reproduce efficiently under favorable conditions and persist during stress. The global strategy that integrates the growth control and stress response remains to be explored. stress tolerance of E. coli, resulting from a global resource re-allocation from ribosome synthesis to the of alanine and arginine, facilitating the adaption of bacteria to nutrient downshift. Our work demonstrates ppGpp enables bacteria to integrate the control of growth and stress response in a seesaw fashion, thus acting as an important global regulator of the bacterial fitness landscape.

引用

页数：16

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