Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

被引：1

作者：

Alves Antunes, Livia Azeredo ^{[1
]}

Fialho, Walter ^{[1
]}

Fernandes, Thais de Oliveira ^{[2
]}

Duarte, Camila ^{[3
]}

Tavares, Jhenyfer da Silva ^{[3
]}

Kuchler, Erika Calvano ^{[4
]}

Antunes, Leonardo Santos ^{[1
]}

机构：

[1] Univ Fed Fluminense UFF, Sch Dent, Postgrad Program Dent, Niteroi, RJ, Brazil

[2] Univ Fed Fluminense UFF, Sch Dent, Dept Specif Format, Nova Friburgo, RJ, Brazil

[3] Univ Fed Fluminense UFF, Sch Biomed, Clin Res Unit, Niteroi, RJ, Brazil

[4] Univ Regensburg, Dept Orthodont, Regensburg, Germany

来源：

BRAZILIAN ORAL RESEARCH | 2023年 / 37卷

关键词：

Genetics; Dental caries; Oral health; Quality of life; children; IMPACT; MTHFR; POLYMORPHISMS; DEPRESSION; VITAMIN-B-12; HOMOCYSTEINE; DISPOSITION; MECHANISMS; ANXIETY; BURDEN;

D O I：

10.1590/1807-3107bor-2023.vol37.0076

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p= 0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.

引用

页数：11

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