Serum Phosphorus, Parathyroid Hormone, and Serum Fibroblast Growth Factor-23 in Egyptian Patients Six Months after Undergoing Living-donor Kidney Transplantation

被引:0
作者
Kamel, Mai Hamed [1 ]
Ahmed, Dina Hesham [1 ]
Mikhael, Emily Samir [1 ]
Abdalla, Mohamed Shehata [1 ]
Sadek, Khaled Marzouk [2 ]
ElNahid, Maggie Said [2 ]
机构
[1] Cairo Univ, Dept Clin & Chem Pathol, Cairo, Egypt
[2] Cairo Univ, Dept Internal Med & Nephrol, Fac Med, Cairo, Egypt
关键词
VITAMIN-D; POSTTRANSPLANT HYPOPHOSPHATEMIA; CALCIUM-METABOLISM; HYPERPARATHYROIDISM; HYPERCALCEMIA; MANAGEMENT; PHOSPHATE; FGF23;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
End-stage renal disease is a major health problem with many complications. Previous studies emphasized the relationship of cardiovascular disease and mortality among these patients to dysregulated phosphate homeostasis. Even after successful renal transplantation, the risk is not eliminated. Several factors seem to interplay to regulate serum phosphorus levels after renal transplantation. Fibroblast growth factor-23 (FGF-23) is a hormone with the major function of inhibiting the reabsorption of phosphate by the renal tubules. Parathormone reduces the reabsorption of phosphate from the proximal tubule of the kidney. The aim of our study was to explore the changes that occurred in FGF-23 and intact parathyroid hormone (iPTH) levels in a cohort of Egyptian patients undergoing renal transplantation and to examine the effect of these factors on posttransplant serum phosphorus levels. The study was carried out prospectively on 37 candidates for live-donor renal transplantation. Serum levels of calcium, phosphorus, iPTH, and FGF-23 were measured before and 6 months after renal transplantation. Statistically significant differences were detected in serum calcium, phosphorus, FGF-23, and iPTH before and 6 months after transplantation (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively). The results also showed a statistically significant correlation between FGF-23 levels and phosphorus levels before transplantation. The interplay between FGF-23 and iPTH has an impact on posttransplant serum phosphorus levels.phosphorus has been linked to graft function, cardiovascular risk, and the survival of the patient and the graft.1 Therefore, screening and managing of posttransplant mineral abnormalities are very important for improving clinical outcomes in renal transplant patients. Hypophosphatemia, persistent elevation of parathyroid hormone (PTH), and persistent elevation of fibroblast growth factor-23 (FGF23) are among the most common complications after transplantation.2 There is, however, some uncertainty regarding the time needed for the normalization of minerals in kidney transplant recipients.3 The aim of our study was to explore the changes in the levels of FGF-23 and intact PTH (iPTH) in a cohort of Egyptian patients 6 months after renal transplantation and to examine the effects of these factors on posttransplant serum phosphorus levels.
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页码:353 / 360
页数:8
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