Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors

被引：9

作者：

Taniguchi, Kohei ^{[1
]}

Goto, Keisuke ^{[2
,3
,4
,5
,6
,7
,8
,9
,10
]}

Yabushita, Hiroki ^{[1
]}

Yamasaki, Rie ^{[1
]}

Ichimura, Koichi ^{[1
]}

机构：

[1] Hiroshima City Hiroshima Citizens Hosp, Dept Pathol, Hiroshima, Japan

[2] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Dept Pathol, Tokyo, Japan

[3] Itabashi Cent Clin Lab, Dept Pathol, Tokyo, Japan

[4] Tokyo Med Univ Hosp, Dept Diagnost Pathol, Tokyo, Japan

[5] Shizuoka Canc Ctr Hosp, Dept Diagnost Pathol, Sunto, Japan

[6] Chutoen Gen Med Ctr, Dept Diagnost Pathol, Kakegawa, Japan

[7] Osaka Int Canc Inst, Dept Diagnost Pathol & Cytol, Osaka, Japan

[8] Osaka Natl Hosp, Dept Diagnost Pathol, Osaka, Japan

[9] Hyogo Canc Ctr, Dept Dermatol, Akashi, Japan

[10] Natl Hosp Org Kagoshima Med Ctr, Dept Dermato Oncol Dermatol, Kagoshima, Japan

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2023年 / 50卷 / 11期

关键词：

cutaneous adnexal tumors; immunohistochemistry; skin; skin tumors; TRPS1; TRICHORHINOPHALANGEAL SYNDROME; PAGETS-DISEASE; BREAST-CANCER; EXPRESSION; IMMUNOHISTOCHEMISTRY; CARCINOMAS; MARKER; GLAND;

D O I：

10.1111/cup.14523

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Transcriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors. Methods: TRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues. Results: The normal epidermis was TRPS1-. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary-like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2/3), nodular hidradenoma (4/5), spiradenoma (4/4), cutaneous mixed tumor (5/5), trichilemmal cyst (7/8), proliferating trichilemmal tumor (1/3), pilomatricoma (9/9), sebaceoma (2/5), extramammary Paget disease (13/13), sebaceous carcinoma (2/2), actinic keratosis (3/10), Bowen disease (7/12), and squamous cell carcinoma (1/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1-. All metastatic breast carcinoma cases (8/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1-. Conclusions: TRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.

引用

页码：1006 / 1013

页数：8