Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials

被引：7

作者：

Chen, Jian-Jiun ^{[1
]}

Wu, Yun-Che ^{[2
]}

Wang, Jun-Sing ^{[3
,4
,5
]}

Lee, Cheng-Hung ^{[2
,5
,6
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Orthoped, Taipei, Taiwan

[2] Taichung Vet Gen Hosp, Dept Orthoped, 1650, Sec 4, Taiwan Blvd, Taichung 40705, Taiwan

[3] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, 1650, Sec 4, Taiwan Blvd, Taichung 40705, Taiwan

[4] Natl Chung Hsing Univ, PhD Program Translat Med, Taichung, Taiwan

[5] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung, Taiwan

[6] Hung Kuang Univ, Dept Food Sci & Technol, Taichung, Taiwan

来源：

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH | 2023年 / 18卷 / 01期

关键词：

Total knee arthroplasty; Liposomal bupivacaine; Traditional periarticular injection; LOCAL INFILTRATION ANALGESIA; MULTIMODAL DRUG INJECTION; INJECTABLE SUSPENSION; DOUBLE-BLIND; TOTAL HIP; TKA; REHABILITATION; PROTOCOL; BENEFIT; HCL;

D O I：

10.1186/s13018-023-03699-4

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

BackgroundLiposomal bupivacaine (LB) is a relatively new formulation that slowly releases bupivacaine to extend its efficacy for 72-96 h. It is inconclusive whether LB offers better efficacy than traditional periarticular injection (TPAI) following total knee arthroplasty (TKA).MethodsRelevant randomized controlled trials (RCTs) were searched using electronic databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. Review Manager 5.4.1 was used for calculations.ResultsSixteen RCTs were included in this meta-analysis. LB had better effects on morphine consumption equivalents during postoperative 24-48 h than TPAI. No significant difference was observed in pain relief, incidence of nausea and vomiting, or length of hospital stay between the two groups.ConclusionLB administration during TKA is not superior to TPAI. Studies with larger sample size are needed to validate our findings.PROSPERO registration number: CRD42022355094.

引用

页数：12

共 37 条

[1] Periarticular Injection of Liposomal Bupivacaine Offers No Benefit Over Standard Bupivacaine in Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial [J].