Cobalt-Catalyzed Asymmetric Hydrosilylation of ?-Oxygenated Ketones

被引：6
|
作者：
Wen, Huiting [1 ]
Chen, Yifei [1 ]
Shi, Lanxuan [1 ]
Chen, Jianhui [1 ]
Luo, Yanshu [1 ]
Xia, Yuanzhi [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 13期
关键词：
ALPHA-HYDROXY KETONES; ENANTIOSELECTIVE HYDROSILYLATION; TRANSFER HYDROGENATION; KINETIC RESOLUTION; 1,2-AMINO ALCOHOLS; TERMINAL EPOXIDES; METAL; IRON; ALKENES; ARYL;
D O I：
10.1021/acs.orglett.3c00162
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric hydrosilylation of alpha-oxygenated ketones was developed under the catalysis of Co(OAc)2 in combination with a chiral phosphine-amido-oxazoline (PAO) ligand, providing a mild, efficient, and enantioselective access to a variety of synthetically useful 1,2-diol derivatives. This protocol can be carried out at the gram scale with a catalyst loading of 1 mol %, and its synthetic utility was demonstrated by efficient conversion of the optically enriched products into chiral alpha-hydroxy acid, 1,3dioxolan-2-one, ethylene oxide, and 1,2,3-1H-triazole.
引用
收藏
页码：2184 / 2189
页数：6
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