The role of LncRNA MCM3AP-AS1 in human cancer

被引：11
作者：
Azizidoost, Shirin [1 ]
Ghaedrahmati, Farhoodeh [2 ]
Sheykhi-Sabzehpoush, Mohadeseh [3 ]
Uddin, Shahab [4 ,5 ]
Ghafourian, Mehri [3 ,6 ]
Salehi, Abdolah Mousavi [3 ]
Keivan, Mona [7 ]
Cheraghzadeh, Maryam [8 ]
Nazeri, Zahra [8 ]
Farzaneh, Maryam [6 ]
Khoshnam, Seyed Esmaeil [9 ]
机构：
[1] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran
[2] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran
[3] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Immunol, Ahvaz, Iran
[4] Hamad Med Corp, Translat Res Inst, Acad Hlth Syst, Doha, Qatar
[5] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, Doha, Qatar
[6] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz, Iran
[7] Kermanshah Univ Med Sci, Fertil & Infertil Res Ctr, Kermanshah, Iran
[8] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Biochem, Ahvaz, Iran
[9] Ahvaz Jundishapur Univ Med Sci, Persian Gulf Physiol Res Ctr, Med Basic Sci Res Inst, Ahvaz, Iran
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2023年 / 25卷 / 01期
关键词：
Cancer; Long non-coding RNAs; MCM3AP-AS1; Signaling pathways; miRNAs; LONG NONCODING RNA; RENAL-CELL CARCINOMA; GASTRIC-CANCER; LUNG-CANCER; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; PROSTATE-CANCER; CERVICAL-CANCER; PROLIFERATION;
D O I：
10.1007/s12094-022-02904-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long noncoding RNAs (lncRNA) play pivotal roles in every level of gene and genome regulation. MCM3AP-AS1 is a lncRNA that has an oncogenic role in several kinds of cancers. Aberrant expression of MCM3AP-AS1 has been reported to be involved in the progression of diverse malignancies, including colorectal, cervical, prostate, lymphoma, lung, ovary, liver, bone, and breast cancers. It is generally believed that MCM3AP-AS1 expression is associated with cancer cell growth, proliferation, angiogenesis, and metastasis. MCM3AP-AS1 by targeting various signaling pathways and microRNAs (miRNAs) presents an important role in cancer pathogenesis. MCM3AP-AS1 as a competitive endogenous RNA has the ability to sponge miRNA, inhibit their expressions, and bind to different target mRNAs related to cancer development. Therefore, MCM3AP-AS1 by targeting several signaling pathways, including the FOX family, Wnt, EGF, and VEGF can be a potent target for cancer prediction and diagnosis. In this review, we will summarize the role of MCM3AP-AS1 in various human cancers.
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页码：33 / 47
页数：15
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