Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study

被引：3

作者：

Kim, Jung-Kyeom ^{[1
,2
]}

Park, Sang -Won ^{[1
,2
]}

Lee, Suk-Hee ^{[3
]}

Kasani, Payam Hosseinzadeh ^{[1
,2
]}

Byeon, Gi Hwan ^{[4
,5
]}

Kim, Yeshin ^{[6
]}

Jang, Jae -Won ^{[1
,2
,6
,7
]}

Lee, Seo-Young ^{[1
,2
,6
,7
]}

机构：

[1] Kangwon Natl Univ Hosp, Dept Neurol, Chunchon, South Korea

[2] Kangwon Natl Univ, Dept Med Bigdata Convergence, Chunchon, South Korea

[3] Kangwon Natl Univ, Stat, Chunchon, South Korea

[4] Kangwon Natl Univ Hosp, Psychiat, Chunchon, South Korea

[5] Kangwon Natl Univ, Psychiat, Sch Med, Chunchon, South Korea

[6] Kangwon Natl Univ, Sch Med, Dept Neurol, Chunchon, South Korea

[7] Kangwon Natl Univ Hosp, Kangwon Natl Univ, Sch Med, Dept Neurol, 156 Baengnyeong Ro, Chunchon 200722, Kangwon, South Korea

来源：

JOURNAL OF CLINICAL NEUROLOGY | 2024年 / 20卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

dementia; fracture; elderly; physical activity; lower-body fracture; OLDER-ADULTS;

D O I：

10.3988/jcn.2022.0257

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower -body fractures. Methods We reconstructed a population -based matched cohort from the National Health Insurance Service-Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea. Results Overall 53,776 subjects with lower -body fractures were identified during 2006-2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower -body fractures who developed dementia from 2008 up to 2015. Lowerbody fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49-1.62) compared with upper -body fractures (aHR=1.19, 95% CI=1.14-1.23). Conclusions These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.

引用

页码：208 / 213

页数：6

共 14 条

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