The effects of antibiotic therapy on neonatal sepsis-associated acute kidney injury

被引：2

作者：

Pevzner, Irina B. ^{[1
,2
]}

Brezgunova, Anna A. ^{[2
,3
]}

Popkov, Vasily A. ^{[1
,2
]}

Sintsov, Mikhail Y.

Andrianova, Nadezda V. ^{[2
]}

Zorova, Ljubava D. ^{[1
,2
]}

Silachev, Denis N. ^{[1
,2
]}

Burov, Artem A. ^{[1
]}

Podurovskaya, Yulia L. ^{[1
]}

Zorov, Dmitry B. ^{[1
,2
]}

Plotnikov, Egor Y. ^{[1
,2
]}

Sukhikh, Gennady T. ^{[1
]}

机构：

[1] VI Kulakov Natl Med Res Ctr Obstet Gynecol & Peri, Moscow, Russia

[2] Lomonosov Moscow State Univ, AN Belozersky Inst Physicochem Biol, Moscow, Russia

[3] Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow, Russia

来源：

LIFE SCIENCES | 2024年 / 338卷

基金：

俄罗斯科学基金会;

关键词：

Inflammation; Kidney damage; Liver injury; Sepsis; GELATINASE-ASSOCIATED LIPOCALIN; INTENSIVE-CARE; INDUCED NEPHROTOXICITY; URINARY CLUSTERIN; RENAL INJURY; BIOMARKERS; SERUM; LIPOPOLYSACCHARIDE; INTERLEUKIN-18; DYSFUNCTION;

D O I：

10.1016/j.lfs.2023.122359

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Neonatal sepsis remains one of the most dangerous conditions in the neonatal intensive care units. One of the organs affected by sepsis is the kidney, making acute kidney injury (AKI) a common complication of sepsis. Treatment of sepsis almost always involves antibiotic therapy, which by itself may cause some adverse effects, including nephrotoxicity. We analyzed the mutual effect of antibiotic therapy and sepsis on AKI in an experimental and clinical study in infants and neonatal rats. Materials and methods: We evaluated the influence of therapy with different antibiotics on the appearance of AKI markers (blood urea nitrogen (BUN), neutrophil gelatinase-associated lipocalin (NGAL), clusterin, interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein 1 (MCP-1), calbindin, glutation-Stransferase subtype pi (GST-pi)) and liver injury markers in newborns with or without clinical signs of sepsis in the intensive care unit. In parallel, we analyzed the development of AKI in experimental lipopolysaccharide (LPS)induced systemic inflammation in newborn rats accompanied by antibiotic therapy. Key findings: We showed that therapy with metronidazole or ampicillin in combination with sulbactam had a beneficial effect in children with suspected sepsis, resulting in a decrease in AKI markers levels. However, treatment of newborns with netilmicin, cefepime, linezolid, or imipenem in combination with cilastatin worsened kidney function in these patients. Significance: This prospective study indicates which antibiotics are preferable in neonatal sepsis and which should be used with caution in view of the risk of AKI development.

引用

页数：11

共 67 条

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