Positive effects of PARP-1 inhibition in KRAS-mutated intrahepatic cholangiocarcinoma is mediated by CHK1 kinase

被引:0
|
作者
Castven, Darko [1 ]
Keggenhoff, Friederike [2 ]
Stojkovic, Stojan [1 ]
Becker, Diana
Castven, Jovana [1 ]
Zimpel, Carolin [1 ]
Straub, Beate [2 ]
Langer, Harald [1 ]
Hahnel, Patrizia
Kindler, Thomas
Fahrer, Jörg [3 ]
Rourke, Colm O. [4 ]
Ma, Lichun [5 ]
Wang, Xin W. [5 ]
Gaiser, Timo [6 ]
Matter, Matthias [7 ]
Sina, Christian [1 ]
Derer, Stefanie [1 ]
Roessler, Stephanie [8 ]
Kaina, Bernd [2 ]
Andersen, Jesper [4 ]
Galle, Peter [2 ]
Marquardt, Jens [1 ]
机构
[1] Univ Klinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
[2] Johannes Gutenberg Univ Mainz, Univ Med, Mainz, Germany
[3] Tech Univ Kaiserslautern, Kaiserslautern, Germany
[4] Biotech Res & Innovat Ctr, Copenhagen, Denmark
[5] NCI, NIH, Bethesda, MD USA
[6] Univ Med Mannheim, Mannheim, Germany
[7] Univ Spital Basel, Basel, Switzerland
[8] Heidelberg Univ, Heidelberg, Germany
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
SAT-230
引用
收藏
页码:S536 / S537
页数:2
相关论文
共 50 条
  • [21] Radiosensitization of pancreatic cancer cells by combined inhibition of Chk1 and PARP1 using AZD7762 and olaparib
    Vance, Sean M.
    Maybuam, Jonathan
    Lawrence, Theodore S.
    Morgan, Meredith A.
    CANCER RESEARCH, 2011, 71
  • [22] DNA repair and stemness determine the sensitizing effect of CHK1, RAD51 and PARP1 inhibition in TNBC
    Meyer, F.
    Becker, S.
    Niecke, A.
    Riepen, B.
    Zielinski, A.
    Werner, S.
    Peitzsch, C.
    Hein, L.
    Dubrovska, A.
    Wikmann, H.
    Windhorst, S.
    Goy, Y.
    Parplys, A. C.
    Petersen, C.
    Rothkamm, K.
    Borgmann, K.
    RADIOTHERAPY AND ONCOLOGY, 2018, 127 : S193 - S194
  • [23] Exploring the Synergy between PARP and CHK1 Inhibition in Matched BRCA2 Mutant and Corrected Cells
    Smith, Hannah L.
    Prendergast, Lisa
    Curtin, Nicola J.
    CANCERS, 2020, 12 (04)
  • [24] Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral TissueNicotinamide and Theophylline on PARP-1 Activity
    C. Allende-Castro
    P. Espina-Marchant
    D. Bustamante
    E. Rojas-Mancilla
    T. Neira
    M. A. Gutierrez-Hernandez
    D. Esmar
    J. L. Valdes
    P. Morales
    P. J. Gebicke-Haerter
    M. Herrera-Marschitz
    Neurotoxicity Research, 2012, 22 : 79 - 90
  • [25] PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
    Caito, Samuel
    Hwang, Jae-woong
    Chung, Sangwoon
    Yao, Hongwei
    Sundar, Isaac K.
    Rahman, Irfan
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 392 (03) : 264 - 270
  • [26] TAK-1 AND THIOREDOXIN METABOLISM INHIBITION: A POTENTIALLY POWERFUL COMBINATION THERAPY FOR KRAS-MUTATED COLON CANCERS
    Hrabe, J.
    Domann, F.
    Spitz, D.
    Mezhir, J.
    DISEASES OF THE COLON & RECTUM, 2014, 57 (05) : E298 - E298
  • [27] Radiosensitization of HPV Positive Head and Neck Squamous Cell Carcinomas (HNSCC) by Chk1 Inhibition
    Busch, C-J
    Kriegs, M.
    Laban, S.
    Tribius, S.
    Knecht, R.
    Petersen, C.
    Dikomey, E.
    Rieckmann, T.
    ONCOLOGY RESEARCH AND TREATMENT, 2014, 37 : 78 - 79
  • [28] TARGETING MYC/MYCN BY INHIBITION OF CHECKPOINT KINASE 1 (CHK1) SENSITIZES PAEDIATRIC GLIOBLASTOMA (PGBM) CELLS TO TEMOZOLOMIDE
    Nandhabalan, Meera
    Bjerke, Lynn
    Vinci, Mara
    Burford, Anna
    Ingram, Wendy
    Mackay, Alan
    von Bueren, Andre
    Baudis, Michael
    Clarke, Paul
    Collins, Ian
    Workman, Paul
    Jones, Chris
    NEURO-ONCOLOGY, 2014, 16 : 49 - 49
  • [29] Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
    Lindsey-Boltz, Laura A.
    Sercin, Oezdemirhan
    Choi, Jun-Hyuk
    Sancar, Aziz
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (48) : 33107 - 33114
  • [30] Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition
    Sarchi, Martina
    Clough, Courtnee A.
    Crosse, Edie I.
    Kim, Jason
    Galvis, Laura D. Baquero
    Aydinyan, Nelli
    Wellington, Rachel
    Yang, Feini
    Galli, Anna
    Creamer, J. Philip
    Stewart, Sintra
    Bradley, Robert K.
    Malcovati, Luca
    Doulatov, Sergei
    BLOOD CANCER DISCOVERY, 2024, 5 (05): : 353 - 370