Secoiridoids from the traditional Chinese medicine Swertia pseudochinensis

被引：3

作者：

Liu, Jie ^{[1
]}

Yan, Qin ^{[2
]}

Wang, Li-Xia ^{[1
]}

He, Xiao-Ping ^{[1
]}

Hu, Hong ^{[1
]}

Liu, Yan-Chun ^{[2
]}

Li, Dan ^{[1
]}

Liu, Yan ^{[1
]}

Guo, Kai ^{[1
]}

Li, Sheng-Hong ^{[1
,2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 210卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Swertia pseudochinensis Hara; Gentianaceae; Secoiridoids; Anti-inflammatory activity; NATURALLY-OCCURRING IRIDOIDS; CHEMICAL-CONSTITUENTS; PART; BIOTRANSFORMATION; GENTIOPICROSIDE; BIOSYNTHESIS; GLUCOSIDES;

D O I：

10.1016/j.phytochem.2023.113642

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Detailed phytochemical investigation on the traditional Chinese medicine Swertia pseudochinensis Hara led to the isolation of ten undescribed secoiridoids and fifteen known analogs. Their structures were elucidated by extensive spectroscopic analysis (including 1D and 2D NMR, and HRESIMS). Selected isolates were assayed for their anti-inflammatory and antibacterial activities, and moderate anti-inflammatory activity via inhibiting the secretion of cytokines IL-6 and TNF-alpha in macrophages RAW264.7 induced by LPS were observed. Antibacterial activity against Staphylococcus aureus was not found at 100 mu M.

引用

页数：8