Potential Therapeutic Effects of Human Amniotic Epithelial Cells on Gynecological Disorders Leading to Infertility or Abortion

被引：0
作者：
Rezayat, Fatemeh [1 ]
Esmaeil, Nafiseh [1 ,2 ,3 ]
Rezaei, Abbas [1 ]
机构：
[1] Isfahan Univ Med Sci, Fac Med, Dept Immunol, Esfahan, Iran
[2] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran
[3] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Environm Res Ctr, Sch Med,Dept Immunol, Esfahan 81744176, Iran
来源：
STEM CELL REVIEWS AND REPORTS | 2023年 / 19卷 / 02期
关键词：
Human amniotic epithelial cells; Immunomodulation; Recurrent spontaneous abortion; Recurrent implantation failure; Premature ovarian failure; PREMATURE OVARIAN FAILURE; REGULATORY T-CELLS; RECURRENT SPONTANEOUS MISCARRIAGE; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; NATURAL-KILLER; IMMUNE-RESPONSES; FETAL MEMBRANES; DIFFERENTIAL EXPRESSION; IMPLANTATION FAILURES;
D O I：
10.1007/s12015-022-10464-3
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The induction of feto-maternal tolerance, fetal non-immunogenicity, and the regulation of mother's immune system are essential variables in a successful pregnancy. Fetal membranes have been used as a source of stem cells and biological components in recent decades. Human amniotic epithelial cells (hAEC) have stem/progenitor characteristics like those found in the amniotic membrane. Based on their immunomodulatory capabilities, recent studies have focused on the experimental and therapeutic applications of hAECs in allograft transplantation, autoimmune disorders, and gynecological problems such as recurrent spontaneous abortion (RSA), recurrent implantation failure (RIF), and premature ovarian failure (POF). This review discusses some of the immunomodulatory features and therapeutic potential of hAECs in preventing infertility, miscarriage, and implantation failure by controlling the maternal immune system.
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收藏
页码：368 / 381
页数：14
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