Host-Pathogen Interactions in K. pneumoniae Urinary Tract Infections: Investigating Genetic Risk Factors in the Taiwanese Population

被引：2

作者：

Chen, Chi-Sheng ^{[1
]}

Hung, Kuo-Sheng ^{[2
]}

Jian, Ming-, Jr. ^{[1
]}

Chung, Hsing-Yi ^{[1
]}

Chang, Chih-Kai ^{[1
]}

Perng, Cherng-Lih ^{[1
]}

Chen, Hsiang-Cheng ^{[3
]}

Chang, Feng-Yee ^{[4
]}

Wang, Chih-Hung ^{[5
]}

Hung, Yi-Jen ^{[6
]}

Shang, Hung-Sheng ^{[1
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pathol, Div Clin Pathol, Taipei 114, Taiwan

[2] Triserv Gen Hosp, Ctr Precis Med & Genom, Natl Def Med Ctr, Taipei, Taiwan

[3] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Rheumatol Immunol & Allergy, Taipei 114, Taiwan

[4] Triserv Gen Hosp, Div Infect Dis & Trop Med, Dept Med, Natl Def Med Ctr, Taipei 114, Taiwan

[5] Triserv Gen Hosp, Natl Def Med Ctr, Dept Otolaryngol Head & Neck Surg, Taipei 114, Taiwan

[6] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Taipei 114, Taiwan

来源：

DIAGNOSTICS | 2024年 / 14卷 / 04期

关键词：

Klebsiella pneumoniae; urinary tract infections; genome-wide association studies; COMMUNITY-ACQUIRED PNEUMONIA; ANNOTATION; EPIDEMIOLOGY; RESPONSES;

D O I：

10.3390/diagnostics14040415

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Klebsiella pneumoniae (K. pneumoniae) urinary tract infections pose a significant challenge in Taiwan. The significance of this issue arises because of the growing concerns about the antibiotic resistance of K. pneumoniae. Therefore, this study aimed to uncover potential genomic risk factors in Taiwanese patients with K. pneumoniae urinary tract infections through genome-wide association studies (GWAS). Methods: Genotyping data are obtained from participants with a history of urinary tract infections enrolled at the Tri-Service General Hospital as part of the Taiwan Precision Medicine Initiative (TPMI). A case-control study employing GWAS is designed to detect potential susceptibility single-nucleotide polymorphisms (SNPs) in patients with K. pneumoniae-related urinary tract infections. The associated genes are determined using a genome browser, and their expression profiles are validated via the GTEx database. The GO, Reactome, DisGeNET, and MalaCards databases are also consulted to determine further connections between biological functions, molecular pathways, and associated diseases between these genes. Results: The results identified 11 genetic variants with higher odds ratios compared to controls. These variants are implicated in processes such as adhesion, protein depolymerization, Ca2+-activated potassium channels, SUMOylation, and protein ubiquitination, which could potentially influence the host immune response. Conclusions: This study implies that certain risk variants may be linked to K. pneumoniae infections by affecting diverse molecular functions that can potentially impact host immunity. Additional research and follow-up studies are necessary to elucidate the influence of these risk variants on infectious diseases and develop targeted interventions for mitigating the spread of K. pneumoniae urinary tract infections.

引用

页数：13

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