Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population

被引：7

作者：

Tomofuji, Yoshihiko ^{[1
,2
,3
,4
]}

Kishikawa, Toshihiro ^{[1
,5
,6
]}

Sonehara, Kyuto ^{[1
,2
,3
,4
]}

Maeda, Yuichi ^{[3
,7
,8
]}

Ogawa, Kotaro ^{[9
]}

Kawabata, Shuhei ^{[10
]}

Oguro-Igashira, Eri ^{[7
,8
]}

Okuno, Tatsusada ^{[9
]}

Nii, Takuro ^{[7
,8
]}

Kinoshita, Makoto ^{[9
]}

Takagaki, Masatoshi ^{[10
]}

Yamamoto, Kenichi ^{[1
,11
,12
]}

Arase, Noriko ^{[13
]}

Yagita-Sakamaki, Mayu ^{[7
,8
]}

Hosokawa, Akiko ^{[9
,14
]}

Motooka, Daisuke ^{[3
,15
]}

Matsumoto, Yuki ^{[15
]}

Matsuoka, Hidetoshi ^{[16
]}

Yoshimura, Maiko ^{[16
]}

Ohshima, Shiro ^{[16
]}

Nakamura, Shota ^{[3
,15
,17
]}

Fujimoto, Manabu ^{[13
]}

Inohara, Hidenori

Kishima, Haruhiko ^{[10
]}

Mochizuki, Hideki ^{[9
]}

Takeda, Kiyoshi ^{[8
,17
,18
]}

Kumanogoh, Atsushi ^{[3
,7
,19
]}

Okada, Yukinori ^{[1
,2
,3
,4
,12
,17
,20
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Stat Genet, Suita 5650871, Japan

[2] RIKEN Ctr Integrat Med Sci, Lab Syst Genet, Tsurumi 2300045, Japan

[3] Osaka Univ, Inst Open & Transdisciplinary Res Initiat, Integrated Frontier Res Med Sci Div, Suita 5650871, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Genome Informat, Tokyo 1138654, Japan

[5] Osaka Univ, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Suita 5650871, Japan

[6] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Nagoya 4648681, Japan

[7] Osaka Univ, Grad Sch Med, Dept Resp Med & Clin Immunol, Suita 5650871, Japan

[8] Osaka Univ, Grad Sch Med, Dept Microbiol & Immunol, Lab Immune Regulat, Suita 5650871, Japan

[9] Osaka Univ, Grad Sch Med, Dept Neurol, Suita 5650871, Japan

[10] Osaka Univ, Grad Sch Med, Dept Neurosurg, Suita 5650871, Japan

[11] Osaka Univ, Grad Sch Med, Dept Pediat, Suita 5650871, Japan

[12] Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Suita 5650871, Japan

[13] Osaka Univ, Grad Sch Med, Dept Dermatol, Suita 5650871, Japan

[14] Suita Municipal Hosp, Dept Neurol, Suita 5648567, Japan

[15] Osaka Univ, Res Inst Microbial Dis, Dept Infect Metagen, Suita 5650871, Japan

[16] NHO Osaka Minami Med Ctr, Dept Rheumatol & Allergol, Kawachi Nagano 5868521, Japan

[17] Osaka Univ, Ctr Infect Dis Educ & Res, Suita 5650871, Japan

[18] Osaka Univ, WPI Immunol Frontier Res Ctr, Suita 5650871, Japan

[19] Osaka Univ, Immunol Frontier Res Ctr, Dept Immunopathol, Suita 5650871, Japan

[20] Osaka Univ, Premium Res Inst Human Metaverse Med WPI PRIMe, Suita 5650871, Japan

来源：

CELL REPORTS | 2023年 / 42卷 / 11期

基金：

日本学术振兴会;

关键词：

GENOME; ASSOCIATION; DEFICIENCY; ALIGNMENT; ACID;

D O I：

10.1016/j.celrep.2023.113324

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interaction between the gut microbiome and host plays a key role in human health. Here, we perform a meta-genome shotgun-sequencing-based analysis of Japanese participants to reveal associations between the gut microbiome, host genetics, and plasma metabolome. A genome-wide association study (GWAS) for microbial species (n = 524) identifies associations between the PDE1C gene locus and Bacteroides intestinalis and be-tween TGIF2 and TGIF2-RAB5IF gene loci and Bacteroides acidifiaciens. In a microbial gene ortholog GWAS, agaE and agaS, which are related to the metabolism of carbohydrates forming the blood group A antigen, are associated with blood group A in a manner depending on the secretor status determined by the East Asian -spe-cific FUT2 variant. A microbiome-metabolome association analysis (n = 261) identifies associations between bile acids and microbial features such as bile acid metabolism gene orthologs including bai and 7b-hydroxys-teroid dehydrogenase. Our publicly available data will be a useful resource for understanding gut microbiome-host interactions in an underrepresented population.

引用

页数：19

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