A Review on Synthesis and Biological Potential of Dihydropyridines

被引：11
作者：
Pathak, Shilpi [1 ]
Jain, Supriya [2 ]
Pratap, Abhishek [1 ]
机构：
[1] GLA Univ, Inst Pharmaceut Res, Mathura 281406, Uttar Pradesh, India
[2] GLA Univ, Inst Business Management, Mathura 281406, Uttar Pradesh, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2024年 / 21卷 / 01期
关键词：
Dihydropyridines; cardiovascular disorders; vasodilation; anti-hypertensive; calcium channels; blood vessels; 1,4-DIHYDROPYRIDINE; ANTIBACTERIAL; DERIVATIVES; PYRIDINE;
D O I：
10.2174/1570180820666230508100955
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Dihydropyridine is an outstanding heterocyclic compound with a wide range of pharmacological potential, including antimicrobial, antioxidant, antitubercular, antiarrhythmic, insecticidal, antihypertensive, vasodilator, anti-inflammatory, antibacterial, antidiabetic and superlative moiety in drug discovery. It is also a versatile pharmacophore, a privileged scaffold, and a distinguished heterocyclic compound. Excellent outcomes have already been shown with novel targets and various modes of action for the dihydropyridines hybrids. This review focused on the mode of action, synthesis, and biological activities. As a result, numerous dihydropyridine candidates are undergoing clinical studies to treat various disorders. This article highlights how novel techniques were used to create dihydropyridines, which may be helpful to researchers in the future.
引用
收藏
页码：15 / 33
页数：19
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