Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

被引：42

作者：

Xu, Xiaoqing ^{[1
,2
]}

Yu, Yixin ^{[3
]}

Ling, Min ^{[3
]}

Ares, Irma ^{[4
,5
]}

Martinez, Marta ^{[4
,5
]}

Lopez-Torres, Bernardo ^{[4
,5
]}

Maximiliano, Jorge-Enrique ^{[4
,5
]}

Martinez-Larranaga, Maria-Rosa ^{[4
,5
]}

Wang, Xu ^{[1
,2
,4
,5
]}

Anadon, Arturo ^{[4
,5
]}

Martinez, Maria-Aranzazu ^{[4
,5
]}

机构：

[1] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China

[2] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China

[3] Huazhong Agr Univ, MAO Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China

[4] Univ Complutense Madrid UCM, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain

[5] Res Inst Hosp 12 Octubre I 12, Madrid 28040, Spain

来源：

ENVIRONMENTAL POLLUTION | 2023年 / 338卷

基金：

中国国家自然科学基金;

关键词：

Toxicity; Lambda-cyhalothrin; Metabolism; Oxidative stress; Mitochondrial damage; IN-VITRO METABOLISM; NF-KAPPA-B; PYRETHROID INSECTICIDE; LIPID-PEROXIDATION; HISTOPATHOLOGICAL ALTERATIONS; PIPERONYL BUTOXIDE; RAT ERYTHROCYTES; PROTECTIVE ROLE; RISK-ASSESSMENT; DEFENSE SYSTEM;

D O I：

10.1016/j.envpol.2023.122694

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Lambda-cyhalothrin, also known as cyhalothrin, is an efficient, broad-spectrum, quick-acting pyrethroid insecticide and acaricide and the most powerful pyrethroid insecticide in the world. However, there is increasing evidence that lambda-cyhalothrin is closely related to a variety of toxicity drawbacks (hepatotoxicity, nephrotoxicity, neurotoxicity and reproductive toxicity, among others) in non-target organisms, and oxidative stress seems to be the main mechanism of toxicity. This manuscript reviews the oxidative and mitochondrial damage induced by lambda-cyhalothrin and the signalling pathways involved in this process, indicating that oxidative stress occupies an important position in lambda-cyhalothrin toxicity. The mechanism of antioxidants to alleviate the toxicity of lambda-cyhalothrin is also discussed. In addition, the metabolites of lambda-cyhalothrin and the major metabolic enzymes involved in metabolic reactions are summarized. This review article reveals a key mechanism of lambda-cyhalothrin toxicity-oxidative damage and suggests that the use of antioxidants seems to be an effective method for preventing toxicity.

引用

页数：18

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