Extreme resistance to the novel siderophore-cephalosporin cefiderocol in an extensively drug-resistant Klebsiella pneumoniae strain causing fatal pneumonia with sepsis: genomic analysis and synergistic combinations for resistance reversal

被引：5

作者：

Daoud, Land ^{[1
]}

Allam, Mushal ^{[2
]}

Collyns, Timothy ^{[3
]}

Ghazawi, Akela ^{[1
]}

Saleem, Aqeel ^{[3
]}

Al-Marzooq, Farah ^{[1
]}

机构：

[1] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Med Microbiol & Immunol, Al Ain, U Arab Emirates

[2] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Genet & Genom, Al Ain, U Arab Emirates

[3] Tawam Hosp, Al Ain, U Arab Emirates

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2023年 / 42卷 / 11期

关键词：

Klebsiella pneumoniae; Cefiderocol; Antibiotic resistance; ST14;

D O I：

10.1007/s10096-023-04671-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Cefiderocol (CFDC) is the first-in-class siderophore-cephalosporin. Klebsiella pneumoniae strain that is extremely resistant to CFDC (MIC: 256 mu g/ml) was isolated for the first time in the United Arab Emirates from a patient with pneumonia and sepsis. It belonged to sequence-type 14 (ST14), with a novel core genome ST. Resistance was driven by the co-expression of beta-lactamases (bla(NDM-1), bla(OXA-232) and bla(CTX-M-15)) and a mutation in catecholate-siderophore receptor, utilized by CFDC to enter the bacterial cell. Synergistic combinations (beta-lactamase inhibitors, aztreonam plus CFDC) re-sensitized the bacteria to CFDC. Although CFDC resistance is multifactorial, the combination with beta-lactamase inhibitors represents a promising approach in resistance reversal for fighting superbugs.

引用

页码：1395 / 1400

页数：6

共 23 条

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