Pd(II)-Catalyzed Cascade Annulation of o-Aminobenzoic Acids with CO, Amines, and Aldehydes to N3-/N1,N3-Substituted 2,3-Dihydroquinazolin-4(1H)-ones

被引：7

作者：

Zhang, Xiaopeng ^{[1
]}

Wang, Jinjun ^{[1
]}

Xu, Jiahui ^{[1
]}

Pang, Qiuyang ^{[1
]}

Liu, Dan ^{[1
]}

Zhang, Guisheng ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine C, NMPA Key Lab Res & Evaluat Innovat Drug, Sch Chem & Chem Engn,Key Lab Green Chem Media & Re, Xinxiang 453007, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 14期

基金：

中国国家自然科学基金;

关键词：

N-ALKYL ANILINES; CATALYZED CARBONYLATION; MEDIATED SYNTHESIS; DERIVATIVES; QUINAZOLIN-4(3H)-ONES; DIHYDROQUINAZOLINONES; QUINAZOLINONES; EVODIAMINE; EFFICIENT; CHLORIDE;

D O I：

10.1021/acs.joc.3c00802

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The unprecedented Pd(II)-catalyzed cascade annulationof o-aminobenzoic acids with CO, amines, and aldehydeshasbeen developed. This protocol provides an efficient and concise approachto selective construction of N3-substituted and N1,N3-disubstituted 2,3-dihydroquinazolin-4(1H)-ones mostly in moderate to excellent yields from simpleand easily available starting materials under mild conditions featuredwith low cost, high step economy, broad substrate scope, and goodproduct diversity.

引用

页码：10266 / 10276

页数：11

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